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Literature summary extracted from

  • Hunt, M.C.; Lindquist, P.J.G.; Peters, J.M.; Gonzalez, F.J.; Diczfalusy, U.; Alexson, S.E.H.
    Involvement of the peroxisome proliferator-activated receptor a in regulating long-chain acyl-CoA thioesterases (2000), J. Lipid Res., 41, 814-823.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.2.2 Clofibrate isozymes CTE-I and MTE-I are induced, induction is completely dependent on PPARalpha Mus musculus
3.1.2.2 Clofibrate induction of all 4 isozymes, mediated through a strictly peroxisome proliferator-activated receptor alpha, PPARalpha, function in gene regulation Mus musculus
3.1.2.2 additional information fat fasting rapidly induces all isozymes, rapidly reversible Mus musculus
3.1.2.2 peroxisome proliferator-activated receptor alpha induction of the isozymes in the liver Mus musculus
3.1.2.2 PPARalpha internal receptor protein essential for effect of stimulating compounds Mus musculus
3.1.2.2 PPARalpha gene expression inducing and regulatory role, mediates the stimulation by clofibrate Mus musculus
3.1.2.2 PPARalpha i.e. peroxisome proliferator-activated receptor alpha Mus musculus
3.1.2.20 Clofibrate isozymes CTE-I and MTE-I are induced, induction is completely dependent on PPARalpha Mus musculus
3.1.2.20 PPARalpha internal receptor protein essential for effect of stimulating compounds Mus musculus
3.1.2.20 PPARalpha gene expression inducing and regulatory role, mediates the stimulation by clofibrate Mus musculus
3.1.2.20 PPARalpha i.e. peroxisome proliferator-activated receptor alpha Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.2.2
-
 Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.2.2 additional information PPARalpha-null mice are not stimulated by clofibrate Mus musculus
3.1.2.20 additional information PPARalpha-null mice are not stimulated by clofibrate Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.2 cytosol isozyme CTE I Mus musculus 5829
-
3.1.2.2 cytosol isozyme CTE-I, diurnal regulation and regulation by fat content of the diet Mus musculus 5829
-
3.1.2.2 mitochondrion isozyme MTE I Mus musculus 5739
-
3.1.2.2 mitochondrion isozyme MTE-I Mus musculus 5739
-
3.1.2.2 peroxisome isozymes PTE-Ia and PTE-Ib Mus musculus 5777
-
3.1.2.2 peroxisome isozmes PTE-Ia and PTE-Ib Mus musculus 5777
-
3.1.2.20 cytosol isozyme CTE I Mus musculus 5829
-
3.1.2.20 mitochondrion isozyme MTE I Mus musculus 5739
-
3.1.2.20 peroxisome isozymes PTE-Ia and PTE-Ib Mus musculus 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.2 acyl-CoA + H2O Mus musculus involved in fatty acid metabolism CoA + a carboxylate
-
 ?
3.1.2.2 additional information Mus musculus enzyme regulation ?
-
 ?
3.1.2.2 additional information Mus musculus isozyme CTE-I: diurnal regulation and regulation by fat content of the diet ?
-
 ?
3.1.2.20 acyl-CoA + H2O Mus musculus involved in fatty acid metabolism CoA + a carboxylate
-
 ?
3.1.2.20 additional information Mus musculus enzyme regulation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.2 Mus musculus
-
 isozymes: cytosolic CTE-I, mitochondrial MTE-I
-
3.1.2.2 Mus musculus
-
 isozymes peroxisomal PTE-Ia and PTE-Ib
-
3.1.2.2 Mus musculus
-
 4 peroxisome proliferator-induced genes, isozymes CTE-I, MTE-I, PTE-Ia, and PTE-Ib
-
3.1.2.20 Mus musculus
-
 isozymes: cytosolic CTE-I, mitochondrial MTE-I
-
3.1.2.20 Mus musculus
-
 isozymes peroxisomal PTE-Ia and PTE-Ib
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.2 liver
-
 Mus musculus
-
3.1.2.20 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.2 acyl-CoA + H2O
-
 Mus musculus CoA + a carboxylate
-
 ?
3.1.2.2 acyl-CoA + H2O involved in fatty acid metabolism Mus musculus CoA + a carboxylate
-
 ?
3.1.2.2 additional information enzyme regulation Mus musculus ?
-
 ?
3.1.2.2 additional information isozyme CTE-I: diurnal regulation and regulation by fat content of the diet Mus musculus ?
-
 ?
3.1.2.2 palmitoyl-CoA + H2O
-
 Mus musculus CoA + palmitate
-
 ?
3.1.2.20 acyl-CoA + H2O
-
 Mus musculus CoA + a carboxylate
-
 ?
3.1.2.20 acyl-CoA + H2O involved in fatty acid metabolism Mus musculus CoA + a carboxylate
-
 ?
3.1.2.20 additional information enzyme regulation Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.2.2 CTE-I
-
 Mus musculus
3.1.2.2 long-chain acyl-CoA thioesterase
-
 Mus musculus
3.1.2.2 MTE-I
-
 Mus musculus
3.1.2.2 PTE-Ia
-
 Mus musculus
3.1.2.2 PTE-Ib
-
 Mus musculus