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Literature summary extracted from
- Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins (2000), J. Biol. Chem., 275, 14212-14216.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.19.12 | gene usp21, DNA sequence determination and analysis, located on chromosome 1q21, expression in COS cells, overexpression in U2O2 cells | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.19.12 | C37A | site-directed mutagenesis | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.19.12 | ubiquitin-protein + H2O | Homo sapiens | important role in regulation of cell growth | ubiquitin + protein | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.19.12 | Homo sapiens | Q9UK80 | gene usp21, dual substrate specificity for ubiquitin- and NEDD8-conjugates | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.19.12 | brain | usp21 gene expression | Homo sapiens | - |
| 3.4.19.12 | heart | usp21 gene expression, high content | Homo sapiens | - |
| 3.4.19.12 | kidney | usp21 gene expression | Homo sapiens | - |
| 3.4.19.12 | liver | usp21 gene expression | Homo sapiens | - |
| 3.4.19.12 | pancreas | usp21 gene expression, high content | Homo sapiens | - |
| 3.4.19.12 | placenta | usp21 gene expression | Homo sapiens | - |
| 3.4.19.12 | skeletal muscle | usp21 gene expression | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.19.12 | additional information | no activity with Sentrin-1-conjugates | Homo sapiens | ? | - |
? | |
| 3.4.19.12 | NEDD8-protein + H2O | enzyme shows dual specificity for ubiquitin-conjugates and NEDD8-conjugates | Homo sapiens | NEDD8 + protein | - |
? | |
| 3.4.19.12 | ubiquitin-protein + H2O | enzyme shows dual specificity for ubiquitin-conjugates and NEDD8-conjugates | Homo sapiens | ubiquitin + protein | - |
? | |
| 3.4.19.12 | ubiquitin-protein + H2O | important role in regulation of cell growth | Homo sapiens | ubiquitin + protein | - |
? | |
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Release 2023.1 (January 2023)
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