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Literature summary extracted from

  • Diczfalusy, M.A.; Björkhem, I.; Einarsson, C.; Hillebrant, C.G.; Alexson, S.E.H.
    Characterization of enzymes involved in formation of ethyl esters of long-chain fatty acids in humans (2001), J. Lipid Res., 42, 1025-1032.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.67 microsome liver, at the lumenal side Homo sapiens
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.67 fatty acid + ethanol Homo sapiens
-
 fatty acyl ethyl ester + H2O responsible for the formation of FAEE, which are mediators of ethanol-induced organ damage ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.67 Homo sapiens
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.67 adipose tissue low activity Homo sapiens
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3.1.1.67 duodenum mucosa, low activity Homo sapiens
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3.1.1.67 gall bladder
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 Homo sapiens
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3.1.1.67 gastric mucosa ventricular, low activity Homo sapiens
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3.1.1.67 heart low activity Homo sapiens
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3.1.1.67 liver highest activity in liver, followed by pancreas Homo sapiens
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3.1.1.67 lung
-
 Homo sapiens
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3.1.1.67 additional information not in serum Homo sapiens
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3.1.1.67 pancreas highest activity in liver, followed by pancreas Homo sapiens
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.67 0.0028
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 pH 7.4, 37°C, liver microsomes Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.67 fatty acid + ethanol
-
 Homo sapiens fatty acyl ethyl ester + H2O
-
 ?
3.1.1.67 fatty acid + ethanol
-
 Homo sapiens fatty acyl ethyl ester + H2O responsible for the formation of FAEE, which are mediators of ethanol-induced organ damage ?
3.1.1.67 additional information FAEE synthase and carboxylesterase activities in liver and pancreas are possibly due to the same protein, that is, carboxylesterase ES-10, which is responsible for the hydrolysis of ethyl palmitate in liver microsomes Homo sapiens ?
-
 ?
3.1.1.67 palmitate + ethanol synthesis of ethyl palmitate is maximal at 0.2-0.4 mM palmitate Homo sapiens ethyl palmitate + H2O
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 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.67 37
-
 assay at Homo sapiens