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Literature summary extracted from

  • Aleryani, S.; Kabakibi, A.; Cluette-Brown, J.; Laposata, M.
    Fatty acid ethyl ester synthase, an enzyme for nonoxidative ethanol metabolism, is present in serum after liver and pancreatic injury (1996), Clin. Chem., 42, 24-27.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.1.67 medicine enzyme is responsible for the formation of fatty acid ethyl esters, which are mediators of ethanol-induced organ damage Homo sapiens
3.1.1.67 medicine patients with liver or pancreatic disease release FAEE synthase into their plasma Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.67 cytosol both cytosolic and membrane-bound Homo sapiens 5829
-
3.1.1.67 membrane both cytosolic and membrane-bound Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.67 fatty acid + ethanol Homo sapiens patients with liver or pancreatic disease release FAEE synthase into their plasma permitting nonoxidative ethanol metabolism in the plasma fatty acyl ethyl ester + H2O responsible for the formation of FAEE, which are mediators of ethanol-induced organ damage ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.67 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.67 erythrocyte substantially lower activity in erythrocytes than in leukocytes Homo sapiens
-
3.1.1.67 leukocyte substantially lower activity in erythrocytes than in leukocytes Homo sapiens
-
3.1.1.67 liver highest activity in liver and pancreas Homo sapiens
-
3.1.1.67 pancreas highest activity in liver and pancreas Homo sapiens
-
3.1.1.67 plasma low activity in normal plasma samples, patients with liver or pancreatic disease release FAEE synthase into their plasma Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.67 arachidonate + ethanol
-
 Homo sapiens ethyl arachidonate + H2O
-
 ?
3.1.1.67 fatty acid + ethanol
-
 Homo sapiens fatty acyl ethyl ester + H2O
-
 ?
3.1.1.67 fatty acid + ethanol patients with liver or pancreatic disease release FAEE synthase into their plasma permitting nonoxidative ethanol metabolism in the plasma Homo sapiens fatty acyl ethyl ester + H2O responsible for the formation of FAEE, which are mediators of ethanol-induced organ damage ?
3.1.1.67 oleate + ethanol
-
 Homo sapiens ethyl oleate + H2O
-
 ?
3.1.1.67 palmitate + ethanol
-
 Homo sapiens ethyl palmitate + H2O
-
 ?
3.1.1.67 stearate + ethanol
-
 Homo sapiens ethyl stearate + H2O
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.67 37
-
 assay at Homo sapiens