EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.67 | Colipase | stimulates hydrolysis of triglycerides, e.g. triolein | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.67 | NaCl | inhibits hydrolysis of triglycerides, e.g. triolein | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.1.67 | cytosol | - |
Homo sapiens | 5829 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.1.1.67 | 50000 | 55000 | gel filtration | Homo sapiens |
3.1.1.67 | 52000 | - |
1 * 52000, SDS-PAGE | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.67 | fatty acid + ethanol | Homo sapiens | important pathway for the metabolism of ingested ethanol, involved in the metabolism of fatty acids, triglycerides and ethanol | fatty acyl ethyl ester + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.67 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.1.1.67 | 1200fold | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.1.67 | pancreas | - |
Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.1.1.67 | 0.04 | - |
pH 7.2, 37°C | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.67 | arachidonate + ethanol | 16.7% of the rate with oleate or linoleate | Homo sapiens | ethyl arachidonate + H2O | - |
? | |
3.1.1.67 | fatty acid + ethanol | - |
Homo sapiens | fatty acyl ethyl ester + H2O | - |
? | |
3.1.1.67 | fatty acid + ethanol | important pathway for the metabolism of ingested ethanol, involved in the metabolism of fatty acids, triglycerides and ethanol | Homo sapiens | fatty acyl ethyl ester + H2O | - |
? | |
3.1.1.67 | linoleate + ethanol | at the same rate as with oleate | Homo sapiens | ethyl linoleate + H2O | - |
? | |
3.1.1.67 | additional information | enzyme has triglyceride lipase activity and also cleaves triglycerides, e.g. triolein, pancreatic fatty acid ethyl ester synthase and triglyceride lipase are likely the same enzymes | Homo sapiens | ? | - |
? | |
3.1.1.67 | additional information | enzyme contains a specific heparin-binding site | Homo sapiens | ? | - |
? | |
3.1.1.67 | oleate + ethanol | ethyl oleate synthesis to hydrolysis ratio of 80:1, at the same rate as with linoleate | Homo sapiens | ethyl oleate + H2O | - |
r | |
3.1.1.67 | palmitate + ethanol | 12.5% of the rate with oleate or linoleate | Homo sapiens | ethyl palmitate + H2O | - |
? | |
3.1.1.67 | stearate + ethanol | 4.2% of the rate with oleate or linoleate | Homo sapiens | ethyl stearate + H2O | - |
? | |
3.1.1.67 | triolein + H2O | hydrolyzes triglycerides, e.g. triolein, 1.25% of the rate of ethyl oleate or ethyl linoleate synthesis | Homo sapiens | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.1.1.67 | monomer | 1 * 52000, SDS-PAGE | Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.1.1.67 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.1.1.67 | 7.2 | - |
assay at | Homo sapiens |