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Literature summary extracted from

  • Singer, S.S.
    Partial purification and some properties of rat liver sulfotransferase I, a glucocorticoid sulfotransferase usually restricted to female rats (1979), Arch. Biochem. Biophys., 196, 340-349.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.18 Cd2+ 5 mM, strong inhibition Rattus norvegicus
2.8.2.18 corticosterone cortisol as substrate, strong Rattus norvegicus
2.8.2.18 dehydroepiandrosterone cortisol as substrate; strong Rattus norvegicus
2.8.2.18 deoxycorticosterone cortisol as substrate, strong Rattus norvegicus
2.8.2.18 dexamethasone cortisol as substrate; weak Rattus norvegicus
2.8.2.18 diethylstilbestrol cortisol as substrate; strong Rattus norvegicus
2.8.2.18 estradiol-17beta cortisol as substrate; strong Rattus norvegicus
2.8.2.18 progesterone cortisol as substrate; strong Rattus norvegicus
2.8.2.18 testosterone cortisol as substrate, strong Rattus norvegicus
2.8.2.18 tetrahydrocortisol cortisol as substrate Rattus norvegicus
2.8.2.18 Zn2+ 5 mM, strong inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.18 0.007
-
cortisol pH 6.8, sulfotransferase I and III Rattus norvegicus
2.8.2.18 0.011
-
3'-phosphoadenylylsulfate pH 6.8, sulfotransferase I Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.18 cytosol
-
Rattus norvegicus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.8.2.18 Ba2+ activation Rattus norvegicus
2.8.2.18 Ba2+ slight Rattus norvegicus
2.8.2.18 Ba2+ 5 mM Rattus norvegicus
2.8.2.18 Ba2+ in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ Rattus norvegicus
2.8.2.18 Ca2+ activation Rattus norvegicus
2.8.2.18 Ca2+ slight Rattus norvegicus
2.8.2.18 Ca2+ 5 mM Rattus norvegicus
2.8.2.18 Ca2+ in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ Rattus norvegicus
2.8.2.18 Co2+ activation Rattus norvegicus
2.8.2.18 Co2+ 5 mM Rattus norvegicus
2.8.2.18 Co2+ in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ Rattus norvegicus
2.8.2.18 Cr2+ activation Rattus norvegicus
2.8.2.18 Cr2+ 5 mM Rattus norvegicus
2.8.2.18 Cr2+ in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ Rattus norvegicus
2.8.2.18 Fe3+ in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ Rattus norvegicus
2.8.2.18 Fe3+ slight activation, 5 mM Rattus norvegicus
2.8.2.18 Mg2+ activation Rattus norvegicus
2.8.2.18 Mg2+ 5 mM Rattus norvegicus
2.8.2.18 Mg2+ in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ Rattus norvegicus
2.8.2.18 Mn2+ activation Rattus norvegicus
2.8.2.18 Mn2+ 5 mM Rattus norvegicus
2.8.2.18 Mn2+ in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ Rattus norvegicus
2.8.2.18 Ni2+ activation Rattus norvegicus
2.8.2.18 Ni2+ slight Rattus norvegicus
2.8.2.18 Ni2+ 5 mM Rattus norvegicus
2.8.2.18 Ni2+ in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.2.18 68000
-
gel filtration Rattus norvegicus
2.8.2.18 156000
-
sulfotransferase I, sedimentation velocity experiments Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.18 3'-phosphoadenylylsulfate + cortisol Rattus norvegicus
-
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.18 Rattus norvegicus
-
female Sprague-Dawley CD rats
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.18 partial Rattus norvegicus
2.8.2.18 sulfotransferase I, restricted to female rats Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.18 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.8.2.18 0.012
-
sulfotransferase I Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
2.8.2.18 -20°C, partially purified preparation, 1 week Rattus norvegicus
2.8.2.18 0-4°C, in crude extracts, 3 days Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.18 3'-phosphoadenylylsulfate + cortisol
-
Rattus norvegicus adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
?
2.8.2.18 3'-phosphoadenylylsulfate + dehydroepiandrosterone
-
Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.18 3'-phosphoadenylylsulfate + deoxycorticosterone
-
Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.18 3'-phosphoadenylylsulfate + estradiol-17beta
-
Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.18 3'-phosphoadenylylsulfate + testosterone
-
Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.18 additional information sulfotransferase I is not as specific as sulfotransferase III Rattus norvegicus ?
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.18 6
-
cortisol as substrate Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.8.2.18 5.3 6.8 about half-maximal activity at pH 5.3 and pH 6.8 Rattus norvegicus
2.8.2.18 6 8.4 about half-maximal activity at pH 6 and pH 8.4 Rattus norvegicus