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Literature summary extracted from

  • Luu-The, V.; Bernier, F.; Dufort, I.
    Steroid sulfotransferases (1996), J. Endocrinol., 150, 87-97.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.8.2.15 medicine characterization of the mechanism of regulation and action of DHEA-ST should lead to a better understanding of the control of adrenal androgen production as well as a better knowledge of the role of DHEAS in the androgen-and estrogen-sensitive disorders Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.15
-
Cavia porcellus
2.8.2.15 DHEA-ST cDNA cloned and sequenced from human adrenal cDNA library, expression vectors transfected into 293 cells, gene hEST, Hugo nomenclature named it STM gene, because it also codes for monoamine-sulfating phenolsulfotransferase M-PST Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.15 cytosol
-
Cavia porcellus 5829
-
2.8.2.15 cytosol
-
Homo sapiens 5829
-
2.8.2.15 cytosol
-
Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.15 3'-phosphoadenylylsulfate + dehydroepiandrosterone Cavia porcellus
-
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
r
2.8.2.15 3'-phosphoadenylylsulfate + dehydroepiandrosterone Rattus norvegicus
-
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
r
2.8.2.15 3'-phosphoadenylylsulfate + dehydroepiandrosterone Homo sapiens conversion of steroids to their inactive sulfated forms, plays a major role in the control of estrogen levels in target tissues adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
r

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.15 Bos taurus
-
bovine
-
2.8.2.15 Cavia porcellus
-
guinea pig
-
2.8.2.15 Homo sapiens
-
human
-
2.8.2.15 Rattus norvegicus
-
rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.15 adrenal gland
-
Cavia porcellus
-
2.8.2.15 adrenal gland
-
Homo sapiens
-
2.8.2.15 adrenal gland
-
Bos taurus
-
2.8.2.15 liver
-
Cavia porcellus
-
2.8.2.15 liver
-
Homo sapiens
-
2.8.2.15 liver
-
Rattus norvegicus
-
2.8.2.15 liver
-
Bos taurus
-
2.8.2.15 placenta
-
Homo sapiens
-
2.8.2.15 placenta
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.15 3'-phosphoadenylylsulfate + 17beta-estradiol
-
Cavia porcellus adenosine 3',5'-bisphosphate + ?
-
r
2.8.2.15 3'-phosphoadenylylsulfate + 17beta-estradiol
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
r
2.8.2.15 3'-phosphoadenylylsulfate + 17beta-estradiol
-
Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
r
2.8.2.15 3'-phosphoadenylylsulfate + 3alpha-hydroxy-5alpha-androstan-17-one
-
Cavia porcellus adenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate
-
r
2.8.2.15 3'-phosphoadenylylsulfate + 3alpha-hydroxy-5alpha-androstan-17-one
-
Homo sapiens adenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate
-
r
2.8.2.15 3'-phosphoadenylylsulfate + allopregnenolone
-
Cavia porcellus adenosine 3',5'-bisphosphate + allopregnenolone sulfate
-
?
2.8.2.15 3'-phosphoadenylylsulfate + dehydroepiandrosterone
-
Cavia porcellus adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
r
2.8.2.15 3'-phosphoadenylylsulfate + dehydroepiandrosterone
-
Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
r
2.8.2.15 3'-phosphoadenylylsulfate + dehydroepiandrosterone
-
Rattus norvegicus adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
r
2.8.2.15 3'-phosphoadenylylsulfate + dehydroepiandrosterone conversion of steroids to their inactive sulfated forms, plays a major role in the control of estrogen levels in target tissues Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
r
2.8.2.15 3'-phosphoadenylylsulfate + pregnenolone
-
Cavia porcellus adenosine 3',5'-bisphosphate + pregnenolone sulfate
-
r
2.8.2.15 3'-phosphoadenylylsulfate + pregnenolone
-
Homo sapiens adenosine 3',5'-bisphosphate + pregnenolone sulfate
-
r
2.8.2.15 3'-phosphoadenylylsulfate + pregnenolone
-
Rattus norvegicus adenosine 3',5'-bisphosphate + pregnenolone sulfate
-
r

Synonyms

EC Number Synonyms Comment Organism
2.8.2.15 DHEA sulphotransferase
-
Homo sapiens
2.8.2.15 DHEA-ST
-
Homo sapiens