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Literature summary extracted from

  • Chen, L.J.
    Bile salt sulfotransferase (1981), Methods Enzymol., 77, 213-218.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.14 adenosine-3',5'-diphosphate
-
 Cavia porcellus
2.8.2.14 adenosine-3',5'-diphosphate
-
 Homo sapiens
2.8.2.14 adenosine-3',5'-diphosphate
-
 Rattus norvegicus
2.8.2.14 ATP
-
 Cavia porcellus
2.8.2.14 ATP
-
 Rattus norvegicus
2.8.2.14 Cu2+
-
 Homo sapiens
2.8.2.14 Cu2+
-
 Rattus norvegicus
2.8.2.14 EDTA
-
 Cavia porcellus
2.8.2.14 EDTA
-
 Rattus norvegicus
2.8.2.14 Fe2+
-
 Homo sapiens
2.8.2.14 Fe2+
-
 Rattus norvegicus
2.8.2.14 iodoacetate
-
 Cavia porcellus
2.8.2.14 iodoacetate
-
 Rattus norvegicus
2.8.2.14 NaN3
-
 Cavia porcellus
2.8.2.14 NaN3
-
 Rattus norvegicus
2.8.2.14 p-chloromercuribenzoate
-
 Cavia porcellus
2.8.2.14 p-chloromercuribenzoate
-
 Homo sapiens
2.8.2.14 p-chloromercuribenzoate
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.14 0.008
-
 3'-phosphoadenylylsulfate pH 6.5, 37°C Rattus norvegicus
2.8.2.14 0.05
-
 taurolithocholate pH 6.5, 37°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.14 cytosol
-
 Homo sapiens 5829
-
2.8.2.14 cytosol
-
 Rattus norvegicus 5829
-
2.8.2.14 cytosol
-
 Mesocricetus auratus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.8.2.14 Co2+
-
 Homo sapiens
2.8.2.14 Co2+
-
 Rattus norvegicus
2.8.2.14 Mg2+
-
 Cavia porcellus
2.8.2.14 Mg2+
-
 Homo sapiens
2.8.2.14 Mg2+
-
 Rattus norvegicus
2.8.2.14 Mn2+
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.2.14 130000
-
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.14 3'-phosphoadenylyl sulfate + taurolithocholate Cavia porcellus
-
 adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
 ?
2.8.2.14 3'-phosphoadenylyl sulfate + taurolithocholate Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.14 Cavia porcellus
-
 guinea pig
-
2.8.2.14 Homo sapiens
-
 human
-
2.8.2.14 Mesocricetus auratus
-
-
-
2.8.2.14 Oryctolagus cuniculus
-
 rabbit
-
2.8.2.14 Rattus norvegicus
-
 rat
-
2.8.2.14 Sus scrofa
-
 pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.14
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.14 adrenal gland
-
 Mesocricetus auratus
-
2.8.2.14 kidney
-
 Rattus norvegicus
-
2.8.2.14 liver
-
 Cavia porcellus
-
2.8.2.14 liver
-
 Homo sapiens
-
2.8.2.14 liver
-
 Rattus norvegicus
-
2.8.2.14 liver
-
 Sus scrofa
-
2.8.2.14 liver
-
 Oryctolagus cuniculus
-
2.8.2.14 liver
-
 Mesocricetus auratus
-
2.8.2.14 small intestine
-
 Mesocricetus auratus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.8.2.14 0.0164
-
-
 Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
2.8.2.14 -20°C, crude enzyme may be stored for several months without loss of enzyme activity Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.14 3'-phosphoadenylyl sulfate + taurolithocholate
-
 Cavia porcellus adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
 ?
2.8.2.14 3'-phosphoadenylyl sulfate + taurolithocholate
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
 ?
2.8.2.14 3'-phosphoadenylyl-sulfate + glycolithocholate
-
 Cavia porcellus adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
 ?
2.8.2.14 3'-phosphoadenylyl-sulfate + glycolithocholate
-
 Homo sapiens adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
 ?
2.8.2.14 3'-phosphoadenylyl-sulfate + glycolithocholate
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
 ?
2.8.2.14 3'-phosphoadenylyl-sulfate + glycolithocholate
-
 Mesocricetus auratus adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
 ?
2.8.2.14 3'-phosphoadenylyl-sulfate + lithocholate
-
 Cavia porcellus adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
 ?
2.8.2.14 3'-phosphoadenylyl-sulfate + lithocholate
-
 Homo sapiens adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
 ?
2.8.2.14 3'-phosphoadenylyl-sulfate + lithocholate
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
 ?
2.8.2.14 3'-phosphoadenylyl-sulfate + lithocholate
-
 Mesocricetus auratus adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
 ?
2.8.2.14 additional information
-
 Homo sapiens ?
-
 ?
2.8.2.14 additional information purified enzyme does not react with estrone, estradiol, testosterone, dehydroepiandrosterone, cholesterol, or cortisol Rattus norvegicus ?
-
 ?

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.8.2.14 Rattus norvegicus
-
-
 5.3