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Literature summary extracted from

  • Yeh, C.T.; Yen, G.C.
    Effects of phenolic acids on human phenolsulfotransferases in relation to their antioxidant activity (2003), J. Agric. Food Chem., 51, 1474-1479.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.2.1 ferulic acid activation of M-PST Homo sapiens
2.8.2.1 gallic acid activation of P-PST and M-PST Homo sapiens
2.8.2.1 gentisic acid activation of P-PST and M-PST Homo sapiens
2.8.2.1 m-coumaric acid activation of P-PST Homo sapiens
2.8.2.1 o-coumaric acid activation of P-PST Homo sapiens
2.8.2.1 p-coumaric acid activation of P-PST Homo sapiens
2.8.2.1 p-hydroxybenzoic acid activation of P-PST and M-PST Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.1 caffeic acid inhibition of P-PST and M-PST Homo sapiens
2.8.2.1 chlorogenic acid inhibition of P-PST and M-PST Homo sapiens
2.8.2.1 protocatechuic acid inhibition of P-PST and M-PST Homo sapiens
2.8.2.1 Sinapic acid inhibition of P-PST and M-PST Homo sapiens
2.8.2.1 syringic acid inhibition of P-PST and M-PST Homo sapiens
2.8.2.1 vanillic acid inhibition of P-PST and M-PST Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.1 3'-phosphoadenylylsulfate + a phenol Homo sapiens sulfate conjugation of phenolic biogenic amines, important in the biotransformation of many neurotransmitters, hormones, drugs, and xenobiotic compounds adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Homo sapiens
-
 2 forms: simple phenol sulfating P-PST, monoamine sulfating M-PST
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.1 platelet M-PST Homo sapiens
-
2.8.2.1 platelet P-PST Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + a phenol
-
 Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-nitrophenol P-PST Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + a phenol sulfate conjugation of phenolic biogenic amines, important in the biotransformation of many neurotransmitters, hormones, drugs, and xenobiotic compounds Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + dopamine M-PST Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.8.2.1 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.1 7
-
 assay at Homo sapiens