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Literature summary extracted from

  • Harris, R.M.; Waring, R.H.; Kirk, C.J.; Hughes, P.J.
    Sulfation of 'estrogenic' alkylphenols and 17beta-estradiol by human platelet phenol sulfotransferases (2000), J. Biol. Chem., 275, 159-166.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.1 1-hydroxy-4-ethylbenzene
-
 Homo sapiens
2.8.2.1 2-Ethylphenol inhibits SULT1A1/2 and SULT1A3 Homo sapiens
2.8.2.1 2-n-propylphenol inhibits SULT1A1/2, but not SULT1A3 Homo sapiens
2.8.2.1 2-sec-Butylphenol inhibits SULT1A1/2, but not SULT1A3 Homo sapiens
2.8.2.1 2-sec-propylphenol inhibits SULT1A1/2 and SULT1A3 Homo sapiens
2.8.2.1 2-tert-butylphenol inhibits SULT1A1/2, but not SULT1A3 Homo sapiens
2.8.2.1 4-n-amylphenol inhibits SULT1A1/2, but not SULT1A3 Homo sapiens
2.8.2.1 4-n-heptylphenol inhibits SULT1A1/2, but not SULT1A3 Homo sapiens
2.8.2.1 4-n-nonylphenol inhibits SULT1A1/2, but not SULT1A3 Homo sapiens
2.8.2.1 4-n-octylphenol inhibits SULT1A1/2, but not SULT1A3 Homo sapiens
2.8.2.1 4-nitrophenol SULT1A1/2 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.1 additional information
-
 additional information kinetics Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.1 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Homo sapiens
-
 SULT1A1/2, a P-PST enzyme form
-
2.8.2.1 Homo sapiens
-
 2 forms: simple phenol sulfating P-PST, monoamine sulfating M-PST
-
2.8.2.1 Homo sapiens
-
 SULT1A3, is a M-PST enzyme form
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.1 platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + a phenol SULT1A1/2: preference for straight chain phenol substrates with C1-2 and C4-5 chain lengths, overview Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + a phenol SULT1A3 is not active with short chain alkylphenols Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 2-ethylphenol SULT1A1/2 Homo sapiens adenosine 3',5'-bisphosphate + 2-ethylphenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 2-methylphenol SULT1A1/2 Homo sapiens adenosine 3',5'-bisphosphate + 2-methylphenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 3-ethylphenol SULT1A1/2 Homo sapiens adenosine 3',5'-bisphosphate + 3-ethylphenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 3-methylphenol SULT1A1/2 Homo sapiens adenosine 3',5'-bisphosphate + 3-methylphenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-ethylphenol SULT1A1/2 Homo sapiens adenosine 3',5'-bisphosphate + 4-ethylphenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-methylphenol SULT1A1/2 Homo sapiens adenosine 3',5'-bisphosphate + 4-methylphenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-n-amylphenol SULT1A1/2 Homo sapiens adenosine 3',5'-bisphosphate + 4-n-amylphenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-n-butylphenol SULT1A1/2 Homo sapiens adenosine 3',5'-bisphosphate + 4-n-butylphenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-n-propylphenol SULT1A1/2 Homo sapiens adenosine 3',5'-bisphosphate + 4-n-propylphenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-nitrophenol SULT1A1/2 Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + dopamine SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 additional information substrate specificity Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.1 SULT
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.8.2.1 0.0052
-
 4-nitrophenol SULT1A1/2, pH 7.0, 37°C Homo sapiens
2.8.2.1 0.0123
-
 1-hydroxy-4-ethylbenzene SULT1A1/2, pH 7.0, 37°C Homo sapiens
2.8.2.1 0.0151
-
 4-n-amylphenol SULT1A1/2, pH 7.0, 37°C Homo sapiens