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Literature summary extracted from

  • Kudlacek, P.E.; Clemens, D.L.; Anderson, R.J.
    Characterization of recombinant human liver thermolabile phenol sulfotransferase with minoxidil as the substrate (1995), Biochem. Biophys. Res. Commun., 210, 363-369.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.1 2,6-Dichloro-4-nitrophenol
-
 Homo sapiens
2.8.2.1 NaCl TL-PST is more resistant to inhibition as TS-PST Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.1 0.011
-
 dopamine
-
 Homo sapiens
2.8.2.1 0.021
-
 3'-phosphoadenylylsulfate with dopamine Homo sapiens
2.8.2.1 0.023
-
 3'-phosphoadenylylsulfate with minoxidil Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.1 3'-phosphoadenylylsulfate + minoxidil Homo sapiens TL- and TS-PST adenosine 3',5'-bisphosphate + minoxidil sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + minoxidil Homo sapiens activation of the substrate adenosine 3',5'-bisphosphate + minoxidil sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Homo sapiens
-
 2 forms: thermolabile TL, thermostable TS
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.1 liver
-
 Homo sapiens
-
2.8.2.1 platelet
-
 Homo sapiens
-
2.8.2.1 skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + a phenol
-
 Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + dopamine
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + minoxidil TL- and TS-PST Homo sapiens adenosine 3',5'-bisphosphate + minoxidil sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + minoxidil activation of the substrate Homo sapiens adenosine 3',5'-bisphosphate + minoxidil sulfate
-
 ?