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Literature summary extracted from

  • Wood, T.C.; Aksoy, I.A.; Aksoy, S.; Weinshilboum, R.M.
    Human liver thermolabile phenol sulfotransferase: cDNA cloning, expression and characterization (1994), Biochem. Biophys. Res. Commun., 198, 1119-1127.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.1 TL-PST, DNA and amino acid sequence determination, in vitro transcription and translation, and expression in COS-1 cells Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.2.1 35500
-
 x * 35500, recombinant TL-PST, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.1 3'-phosphoadenylylsulfate + a phenol Homo sapiens sulfate conjugation of phenolic biogenic amines, important in the biotransformation of many neurotransmitters, hormones, drugs, and xenobiotic compounds adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Homo sapiens
-
 2 forms: thermolabile TL, thermostable TS
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.1 TL-PST Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.1 brain TL-PST Homo sapiens
-
2.8.2.1 jejunum mucosa, TL-PST Homo sapiens
-
2.8.2.1 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + a phenol
-
 Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + 4-nitrophenol
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + a phenol sulfate conjugation of phenolic biogenic amines, important in the biotransformation of many neurotransmitters, hormones, drugs, and xenobiotic compounds Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + dehydroepiandrosterone
-
 Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + dopamine
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.8.2.1 ? x * 35500, recombinant TL-PST, SDS-PAGE Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.8.2.1 37.6
-
 liver TL-PST, 50% inactivation at Homo sapiens
2.8.2.1 40.4
-
 liver TS-PST, 50% inactivation at Homo sapiens