Literature summary extracted from

Ollagnier-de Choudens, S.; Sanakis, Y.; Hewitson, K.S.; Roach, P.; Munck, E.; Fontecave, M.
Reductive cleavage of S-adenosylmethionine by biotin synthase from Escherichia coli (2002), J. Biol. Chem., 277, 13449-13454.

Protein Variants

EC Number	Protein Variants	Comment	Organism
2.8.1.6	C128A	no enzyme activity	Escherichia coli
2.8.1.6	C188A	no enzyme activity	Escherichia coli
2.8.1.6	C53A	no enzyme activity	Escherichia coli
2.8.1.6	C57A	no enzyme activity	Escherichia coli
2.8.1.6	C60A	no enzyme activity	Escherichia coli
2.8.1.6	C97A	no enzyme activity	Escherichia coli

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
2.8.1.6	Iron	[4Fe-4S] is involved in cleavage of S-adenosylmethionine	Escherichia coli

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.8.1.6	Escherichia coli	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.8.1.6	dethiobiotin + sulfur	-	Escherichia coli	biotin	-	?

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Release 2023.1 (January 2023)