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Literature summary extracted from

  • Sanyal, I.; Gibson, K.J.; Flint, D.H.
    Escherichia coli biotin synthase: an investigation into the factors required for its activity and its sulfur donor (1996), Arch. Biochem. Biophys., 326, 48-56.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.1.6 dithiothreitol potential sulfur donor Escherichia coli
2.8.1.6 fructose 1,6-diphosphate
-
 Escherichia coli
2.8.1.6 L-cysteine required Escherichia coli
2.8.1.6 additional information a labile low-molecular-weight product of the 7,8-diaminoperlargonic acid aminotransferase reaction stimulates by 3fold Escherichia coli
2.8.1.6 S-adenosyl-L-methionine required Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.1.6 dethiobiotin + sulfur Escherichia coli catalyzes the last step of the biosynthesis of biotin biotin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.1.6 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.1.6 dethiobiotin + sulfur
-
 Escherichia coli biotin
-
 ?
2.8.1.6 dethiobiotin + sulfur catalyzes the last step of the biosynthesis of biotin Escherichia coli biotin
-
 ?
2.8.1.6 additional information cysteine and S-adenosylmethionine are no sulfur donors Escherichia coli ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.8.1.6 flavodoxin required Escherichia coli
2.8.1.6 NADPH enhances activity Escherichia coli