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Literature summary extracted from

  • Joshi, A.K.; Zhang, L.; Rangan, V.S.; Smith, S.
    Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity (2003), J. Biol. Chem., 278, 33142-33149.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.7 cloned and expressed in Sf9 insect cells Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.8.7 0.0031
-
 apo-acyl-carrier protein pH 7.0, 37°C, human acyl carrier protein f as as substrate Homo sapiens
2.7.8.7 0.0064
-
 apo-peptidyl carrier protein pH 7.0, 37°C Homo sapiens
2.7.8.7 0.0075
-
 apo-acyl-carrier protein pH 7.0, 37°C, human acyl carrier protein mit as substrate Homo sapiens
2.7.8.7 0.021
-
 apo-ACP pH 7.0, 37°C, Bacillus subtilis acyl carrier protein-A as substrate Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.7 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.7 CoA + apo-[acyl-carrier protein] Homo sapiens
-
 adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
 r
2.7.8.7 CoA + apo-[alpha-aminoadipate semialdehyde dehydrogenase] Homo sapiens phosphopantetheinylation of the enzyme involved in lysine catabolism adenosine 3',5'-bisphosphate + holo-[alpha-aminoadipate semialdehyde dehydrogenase]
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.7 Homo sapiens
-
 human
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.7 CoA + apo-[acyl-carrier protein]
-
 Homo sapiens adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
 r
2.7.8.7 CoA + apo-[alpha-aminoadipate semialdehyde dehydrogenase] phosphopantetheinylation of the enzyme in volved in lysine catabolism Homo sapiens adenosine 3',5'-bisphosphate + holo-[alpha-aminoadipate semialdehyde dehydrogenase]
-
 r
2.7.8.7 CoA + apo-[alpha-aminoadipate semialdehyde dehydrogenase] phosphopantetheinylation of the enzyme involved in lysine catabolism Homo sapiens adenosine 3',5'-bisphosphate + holo-[alpha-aminoadipate semialdehyde dehydrogenase]
-
 r
2.7.8.7 CoA + apo-[peptidyl carrier protein]
-
 Homo sapiens adenosine 3',5'-bisphosphate + holo-[peptidyl-carrier protein]
-
 r
2.7.8.7 additional information single broad specificity enzyme for all posttranslational 4'-phosphopantetheinylation reactions, also capable of phosphopantetheinylation of peptidyl carrier and acyl carrier proteins from prokaryotes Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.8.7 monomer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.8.7 4'-phosphopantetheinyl transferase
-
 Homo sapiens
2.7.8.7 human PPTase
-
 Homo sapiens