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Literature summary extracted from

  • Chandra, N.C.; Doody, M.B.; Bretthauer, R.K.
    Specific lipids enhance the activity of UDP-GlcNAc: dolichol phosphate GlcNAc-1-phosphate transferase in rat liver endoplasmic reticulum membrane vesicles (1991), Arch. Biochem. Biophys., 290, 345-354.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.8.15 cardiolipin stimulates activity of enzyme in endoplasmic membrane vesicles, due to better solubilization of the dolichol phosphate Rattus norvegicus
2.7.8.15 monogalactosyldiglyceride stimulates activity of enzyme in endoplasmic membrane vesicles Rattus norvegicus
2.7.8.15 phosphatidylethanolamine stimulates activity of enzyme in endoplasmic membrane vesicles Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.15 Triton X-100 substrate protects from inhibition Rattus norvegicus
2.7.8.15 tunicamycin
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.8.15 additional information
-
 additional information Km-value for dolichyl phosphate: 0.005 mg/0.1 ml Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.15 endoplasmic reticulum
-
 Rattus norvegicus 5783
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.15 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.15 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.15 UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
-
 Rattus norvegicus UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.8.15 40
-
 with 0.5% Triton X-100 in the assay mixture Rattus norvegicus
2.7.8.15 60
-
 with either dioleoylphosphatidylethanolamine or cardiolipin in the assay mixture Rattus norvegicus