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Literature summary extracted from

  • Fiedler, F.; Glaser, L.
    The synthesis of polyribitol phosphate. I. Purification of polyribitol phosphate polymerase and lipoteichoic acid carrier (1974), J. Biol. Chem., 249, 2684-2689.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.8.14 cardiolipin stimulates 6fold at 0.36 mM Staphylococcus aureus
2.7.8.14 lipoteichoic acid required as carrier Staphylococcus aureus
2.7.8.14 phosphatidylcholine stimulates 2.7fold 0.36 mM Staphylococcus aureus
2.7.8.14 phosphatidylethanolamine stimulates 5fold 0.36 mM Staphylococcus aureus
2.7.8.14 phosphatidylglycerol stimulates 4fold 0.36 mM Staphylococcus aureus
2.7.8.14 Phospholipid required Staphylococcus aureus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.14 4-hydroxymercuribenzoate inhibition at 0.4 mM, can be reversed by 2-mercaptoethanol Staphylococcus aureus
2.7.8.14 CDPglycerol weak Staphylococcus aureus
2.7.8.14 CMP
-
 Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.14 CDPribitol + (ribitol phosphate)n Staphylococcus aureus
-
 CMP + (ribitol phosphate)n+1
-
 ?
2.7.8.14 CDPribitol + (ribitol phosphate)n Staphylococcus aureus H
-
 CMP + (ribitol phosphate)n+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.14 Staphylococcus aureus
-
 H
-
2.7.8.14 Staphylococcus aureus H
-
 H
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.8.14 400fold Staphylococcus aureus

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.8.14 0.0035
-
-
 Staphylococcus aureus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.14 CDPribitol + (ribitol phosphate)n
-
 Staphylococcus aureus CMP + (ribitol phosphate)n+1
-
 ?
2.7.8.14 CDPribitol + (ribitol phosphate)n
-
 Staphylococcus aureus H CMP + (ribitol phosphate)n+1
-
 ?
2.7.8.14 CDPribitol + lipoteichoic acid
-
 Staphylococcus aureus lipoteichoic acid-(P-ribitol)n + CMP
-
 ?
2.7.8.14 CDPribitol + lipoteichoic acid
-
 Staphylococcus aureus H lipoteichoic acid-(P-ribitol)n + CMP
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.7.8.14 25
-
 24 h, very stable Staphylococcus aureus