BRENDA - Enzyme Database

Alternative substrate and inhibition kinetics of aminoglycoside nucleotidyltransferase 2''-I in support of a Theorell-Chance kinetic mechanism

Gates, C.A.; Northrop, D.B.; Biochemistry 27, 3826-3833 (1988)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
2.7.7.46
medicine
application of alternative substrate diagnostic
Escherichia coli
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.7.46
neomycin C
dead-end inhibition, uncompetitive versus MgATP2-
Escherichia coli
2.7.7.46
sisomicin
uncompetitive substrate inhibition
Escherichia coli
2.7.7.46
tobramycin
substrate inhibition, uncompetitive versus MgATP2-
Escherichia coli
Organism
EC Number
Organism
UniProt
Commentary
Textmining
2.7.7.46
Escherichia coli
-
-
-
2.7.7.46
Escherichia coli W677/pMY10
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
2.7.7.46
ATP + gentamicin A
gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors
645289
Escherichia coli
diphosphate + 2''-adenylylgentamicin A
-
-
-
r
2.7.7.46
ATP + gentamicin A
gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors
645289
Escherichia coli W677/pMY10
diphosphate + 2''-adenylylgentamicin A
-
-
-
r
2.7.7.46
ATP + gentamicin C1
gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors
645289
Escherichia coli
diphosphate + 2''-adenylylgentamicin C1
-
-
-
?
2.7.7.46
ATP + gentamicin C1
gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors
645289
Escherichia coli W677/pMY10
diphosphate + 2''-adenylylgentamicin C1
-
-
-
?
2.7.7.46
ATP + gentamicin C1a
gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors
645289
Escherichia coli
diphosphate + 2''-adenylylgentamicin C1a
-
-
-
?
2.7.7.46
ATP + neomycin C
-
645289
Escherichia coli
diphosphate + 2''-adenylylneomycin C
-
-
-
r
2.7.7.46
ATP + neomycin C
-
645289
Escherichia coli W677/pMY10
diphosphate + 2''-adenylylneomycin C
-
-
-
r
2.7.7.46
ATP + sisomicin
-
645289
Escherichia coli
diphosphate + 2''-adenylylsisomicin
-
-
-
r
2.7.7.46
ATP + sisomicin
-
645289
Escherichia coli W677/pMY10
diphosphate + 2''-adenylylsisomicin
-
-
-
r
2.7.7.46
ATP + tobramycin
-
645289
Escherichia coli
diphosphate + 2''-adenylyltobramycin
-
-
-
r
2.7.7.46
ATP + tobramycin
-
645289
Escherichia coli W677/pMY10
diphosphate + 2''-adenylyltobramycin
-
-
-
r
Synonyms
EC Number
Synonyms
Commentary
Organism
2.7.7.46
aminoglycoside nucleotidyltransferase 2''-I
-
Escherichia coli
2.7.7.46
ANT(2'')-I
-
Escherichia coli
Application (protein specific)
EC Number
Application
Commentary
Organism
2.7.7.46
medicine
application of alternative substrate diagnostic
Escherichia coli
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.7.46
neomycin C
dead-end inhibition, uncompetitive versus MgATP2-
Escherichia coli
2.7.7.46
sisomicin
uncompetitive substrate inhibition
Escherichia coli
2.7.7.46
tobramycin
substrate inhibition, uncompetitive versus MgATP2-
Escherichia coli
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
2.7.7.46
ATP + gentamicin A
gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors
645289
Escherichia coli
diphosphate + 2''-adenylylgentamicin A
-
-
-
r
2.7.7.46
ATP + gentamicin A
gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors
645289
Escherichia coli W677/pMY10
diphosphate + 2''-adenylylgentamicin A
-
-
-
r
2.7.7.46
ATP + gentamicin C1
gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors
645289
Escherichia coli
diphosphate + 2''-adenylylgentamicin C1
-
-
-
?
2.7.7.46
ATP + gentamicin C1
gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors
645289
Escherichia coli W677/pMY10
diphosphate + 2''-adenylylgentamicin C1
-
-
-
?
2.7.7.46
ATP + gentamicin C1a
gentamicin A, C1 and C1a, MgATP2-, MgdATP2- and MgdGTP2- can act as donors
645289
Escherichia coli
diphosphate + 2''-adenylylgentamicin C1a
-
-
-
?
2.7.7.46
ATP + neomycin C
-
645289
Escherichia coli
diphosphate + 2''-adenylylneomycin C
-
-
-
r
2.7.7.46
ATP + neomycin C
-
645289
Escherichia coli W677/pMY10
diphosphate + 2''-adenylylneomycin C
-
-
-
r
2.7.7.46
ATP + sisomicin
-
645289
Escherichia coli
diphosphate + 2''-adenylylsisomicin
-
-
-
r
2.7.7.46
ATP + sisomicin
-
645289
Escherichia coli W677/pMY10
diphosphate + 2''-adenylylsisomicin
-
-
-
r
2.7.7.46
ATP + tobramycin
-
645289
Escherichia coli
diphosphate + 2''-adenylyltobramycin
-
-
-
r
2.7.7.46
ATP + tobramycin
-
645289
Escherichia coli W677/pMY10
diphosphate + 2''-adenylyltobramycin
-
-
-
r