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Literature summary extracted from

  • Shama Bhat, C.; Ramasarma, T.
    Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds (1979), Biochem. J., 181, 143-151.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.2 4-hydroxybenzaldehyde 2.5 mM, 11% inhibition Rattus norvegicus
2.7.4.2 4-hydroxybenzoic acid 2.5 mM, 28% inhibition Rattus norvegicus
2.7.4.2 4-hydroxyphenylpropionic acid 2.5 mM, 46% inhibition Rattus norvegicus
2.7.4.2 Anisic acid 2.5 mM, 27% inhibition Rattus norvegicus
2.7.4.2 Cinnamic acid 2.5 mM, 28% inhibition Rattus norvegicus
2.7.4.2 isoferulic acid 2.5 mM, 64% inhibition Rattus norvegicus
2.7.4.2 m-coumaric acid 2.5 mM, 70% inhibition Rattus norvegicus
2.7.4.2 p-coumaric acid 1.25 mM, 46% inhibition Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.2 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.2 ATP + 5-phosphomevalonate
-
 Rattus norvegicus ADP + 5-diphosphomevalonate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.4.2 2.39
-
 p-coumaric acid pH 7.4, 37°C Rattus norvegicus
2.7.4.2 2.48
-
 Cinnamic acid pH 7.4, 37°C Rattus norvegicus
2.7.4.2 3.85
-
 isoferulic acid pH 7.4, 37°C Rattus norvegicus