EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.4.14 | CuSO4 | 0.25 mM, 96% inhibition of enzyme form UMPK1 and 92% inhibition of enzyme form UMPK2 | Homo sapiens | |
2.7.4.14 | HgCl2 | 0.25 mM, complete inhibition of enzyme form UMPK1 and UMPK2 | Homo sapiens | |
2.7.4.14 | lead nitrate | 0.25 mM, 52% inhibition of enzyme form UMPK1 and 40% inhibition of enzyme form UMPK2 | Homo sapiens | |
2.7.4.14 | ZnCl2 | 0.25 mM, 55% inhibition of enzyme form UMPK1 and 30% inhibition of enzyme form UMPK2 | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.4.14 | 0.026 | - |
CMP | 37°C enzyme form UMPK 1 | Homo sapiens | |
2.7.4.14 | 0.028 | - |
CMP | 37°C, enzyme form UMPK2 | Homo sapiens | |
2.7.4.14 | 0.053 | - |
UMP | 37°C, enzyme form UMPK1 | Homo sapiens | |
2.7.4.14 | 0.064 | - |
UMP | 37°C, enzyme form UMPK2 | Homo sapiens | |
2.7.4.14 | 0.25 | - |
ATP | 37°C, enzyme form UMPK2 | Homo sapiens | |
2.7.4.14 | 0.36 | - |
ATP | 37°C, enzyme form UMPK1 | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.4.14 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.4.14 | partial, two allelic gene products UMPK1 and UMPK2 | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.4.14 | erythrocyte | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.4.14 | ATP + AMP | - |
Homo sapiens | ADP + ADP | - |
r | |
2.7.4.14 | ATP + CMP | - |
Homo sapiens | ADP + CDP | - |
? | |
2.7.4.14 | ATP + dUMP | - |
Homo sapiens | ADP + dUDP | - |
? | |
2.7.4.14 | ATP + UMP | - |
Homo sapiens | ADP + UDP | - |
? |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.4.14 | 25 | - |
30 min, stable | Homo sapiens |
2.7.4.14 | 40 | - |
30 min, enzyme form UMPK2 loses 70% of maximal activity, enzyme form UMPK1 loses 30% of its activity | Homo sapiens |
2.7.4.14 | 45 | - |
30 min, enzyme form UMPK2 loses more than 80% of maximal activity, enzyme form UMPK1 loses more than 60% of its activity | Homo sapiens |
2.7.4.14 | 50 | - |
30 min, enzyme forms UMPK2 and UMPK1 lose 90% of its activity | Homo sapiens |