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Literature summary extracted from

  • Wilson, D.B; Prescott, S.M.; Majerus, P.W.
    Discovery of an arachidonoyl coenzyme A synthetase in human platelets (1982), J. Biol. Chem., 257, 3510-3515.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.15 8,11,14-Eicosatrienoate
-
 Homo sapiens
6.2.1.15 arachidonate unlabeled arachidonate inhibits arachidonate activation Homo sapiens
6.2.1.15 eicosapentaenoate slight Homo sapiens
6.2.1.15 oleate not Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2.1.15 0.03
-
 arachidonate
-
 Homo sapiens
6.2.1.15 0.13
-
 CoA
-
 Homo sapiens
6.2.1.15 0.5
-
 ATP
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.15 membrane
-
 Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.15 Mg2+ required Homo sapiens
6.2.1.15 Mg2+ Km: 2.5 mM Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.15 ATP + arachidonate + CoA Homo sapiens enzyme may control the level of free arachidonate in platelets, limiting prostaglandin synthesis by the unstimulated cell and capturing free arachidonate from extracellular sources ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.15 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.15 blood platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.15 ATP + 8,11,14-eicosatrienoate + CoA
-
 Homo sapiens AMP + diphosphate + 8,11,14-eicosatrienoyl-CoA
-
 ?
6.2.1.15 ATP + arachidonate + CoA
-
 Homo sapiens AMP + diphosphate + arachidonoyl-CoA
-
 ?
6.2.1.15 ATP + arachidonate + CoA enzyme may control the level of free arachidonate in platelets, limiting prostaglandin synthesis by the unstimulated cell and capturing free arachidonate from extracellular sources Homo sapiens ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2.1.15 8
-
-
 Homo sapiens