EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.31 | ADP | requirement | Rattus norvegicus | |
2.7.11.31 | alpha,beta-methylene-ADP | allosteric activator, can replace ADP, with 66% efficiency with bovine serum albumin as substrate | Rattus norvegicus | |
2.7.11.31 | CDP | allosteric activator | Rattus norvegicus | |
2.7.11.31 | additional information | not activated by cAMP | Rattus norvegicus | |
2.7.11.31 | UDP | allosteric activator | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.11.31 | 0.14 | - |
ATP | pH 7.5, 37°C | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.11.31 | cytosol | - |
Rattus norvegicus | 5829 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.7.11.31 | 56000 | - |
x * 56000, SDS-PAGE | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.31 | ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | Rattus norvegicus | inactivates EC 1.1.1.34 by phosphorylation | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.31 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.11.31 | - |
Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.31 | liver | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.7.11.31 | additional information | - |
3.130 nU/mg | Rattus norvegicus |
EC Number | Storage Stability | Organism |
---|---|---|
2.7.11.31 | -196°C, stored in liquid nitrogen, stable for several months | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.31 | ATP + bovine serum albumin | fraction V | Rattus norvegicus | ADP + [bovine serum albumin] phosphate | - |
? | |
2.7.11.31 | ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | - |
Rattus norvegicus | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
2.7.11.31 | ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | inactivates EC 1.1.1.34 by phosphorylation | Rattus norvegicus | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
2.7.11.31 | dATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | phosphorylation at about 90% the rate of ATP | Rattus norvegicus | dADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
2.7.11.31 | GTP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | phosphorylation at about 30% the rate of ATP | Rattus norvegicus | GDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
2.7.11.31 | ITP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | phosphorylation at about 10% the rate of ATP | Rattus norvegicus | IDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
2.7.11.31 | UTP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | phosphorylation at about 5% the rate of ATP | Rattus norvegicus | UDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.7.11.31 | ? | x * 56000, SDS-PAGE | Rattus norvegicus |