EC Number | General Stability | Organism |
---|---|---|
2.7.11.31 | about 10% decrease of activity after each freeze-thawing | Rattus norvegicus |
2.7.11.31 | very stable at either 4°C or -20°C when in microsomes | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.31 | glycerol | 25% v/v, reversible inhibition | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.11.31 | cytosol | - |
Rattus norvegicus | 5829 | - |
2.7.11.31 | microsome | - |
Rattus norvegicus | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.31 | Mg2+ | - |
Rattus norvegicus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.7.11.31 | 105000 | - |
2 * 105000, SDS-PAGE | Rattus norvegicus |
2.7.11.31 | 205000 | - |
gel filtration | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.31 | ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | Rattus norvegicus | inactivates EC 1.1.1.34 by phosphorylation | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
2.7.11.31 | ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | Rattus norvegicus Sprague-Dawley | inactivates EC 1.1.1.34 by phosphorylation | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.31 | Rattus norvegicus | - |
Sprague-Dawley | - |
2.7.11.31 | Rattus norvegicus Sprague-Dawley | - |
Sprague-Dawley | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.11.31 | - |
Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.31 | liver | - |
Rattus norvegicus | - |
EC Number | Storage Stability | Organism |
---|---|---|
2.7.11.31 | -80°C, in 0.05 M Tris-HCl buffer, pH 7.4, 0.05 M NaF, 0.003 M EDTA, 0.002 M EGTA, 0.005 M DTT, 0.5 mM PMSF, 10% v/v glycerol, remains stable for at least 3 months | Rattus norvegicus |
2.7.11.31 | 4°C, unstable when solubilized, loses 90% activity within 3 days | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.31 | ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | - |
Rattus norvegicus | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
2.7.11.31 | ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | inactivates EC 1.1.1.34 by phosphorylation | Rattus norvegicus | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
2.7.11.31 | ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | - |
Rattus norvegicus Sprague-Dawley | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
2.7.11.31 | ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | inactivates EC 1.1.1.34 by phosphorylation | Rattus norvegicus Sprague-Dawley | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
2.7.11.31 | additional information | autophosphorylation in absence of substrate | Rattus norvegicus | ? | - |
? | |
2.7.11.31 | additional information | autophosphorylation in absence of substrate | Rattus norvegicus Sprague-Dawley | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.7.11.31 | dimer | 2 * 105000, SDS-PAGE | Rattus norvegicus |