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Literature summary extracted from

  • Ramauge, M.; Pallud, S.; Esfandiari, A.; Gavaret, J.; Lennon, A.; Pierre, M.; Courtin, F.
    Evidence that type III iodothyronine deiodinase in rat astrocyte is a selenoprotein (1996), Endocrinology, 137, 3021-3025.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.21.99.3 12-O-tetradecanoylphorbol-13-acetate induction of isozyme type III from brain astrocytes Rattus norvegicus
1.21.99.3 acidic fibroblast growth factor slight increase of 3,3',5,5'-tetraiodo-L-thyronine 5-deiodinase activity by isozyme type III Rattus norvegicus
1.21.99.3 acidic fibroblast growth factor induction of isozyme type III 3,3',5-triiodo-L-thyronine 5-deiodinase activity from brain astrocytes, 6fold higher in Se-repleted than in depleted cells Rattus norvegicus
1.21.99.3 actinomycin D induction of isozyme type III from brain astrocytes Rattus norvegicus
1.21.99.3 cAMP induction of isozyme type III from brain astrocytes Rattus norvegicus
1.21.99.3 retinoic acid induction of isozyme type III from brain astrocytes Rattus norvegicus
1.21.99.3 Se2+ required, depletion reversibly reduces the activity of isozyme type III by 3-10fold in cultured brain astrocytes Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.99.3 aurothioglucose no inhibition, isozyme type III Rattus norvegicus
1.21.99.3 cycloheximide isozyme type III, slight decrease of activity in vivo Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.21.99.3 0.000001
-
 3,3',5-triiodo-L-thyronine pH 7.4, 37°C Rattus norvegicus
1.21.99.3 0.000001
-
 3,3',5-triiodo-L-thyronine not influenced by selenium-deficiency Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.3 Rattus norvegicus
-
 selenoprotein
-
1.21.99.3 Rattus norvegicus
-
 isozyme type III
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.3 astrocyte cell culture Rattus norvegicus
-
1.21.99.3 astrocyte isozyme type III Rattus norvegicus
-
1.21.99.3 cell culture astrocytes Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 isozyme type III Rattus norvegicus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 preferred substrate Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 isozyme type III Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 5-deiodinase activity Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.21.99.3 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.21.99.3 7.4
-
 assay at Rattus norvegicus