EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.21.99.3 | aurothioglucose | 3,3',5,5'-tetraiodo-L-thyronine 5-deiodinase activity | Homo sapiens | |
1.21.99.3 | iopanoic acid | 3,3',5,5'-tetraiodo-L-thyronine 5-deiodinase activity | Homo sapiens | |
1.21.99.3 | additional information | no inhibition of 5-deiodinase activity by propylthiouracil | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.21.99.3 | 0.000107 | - |
L-thyroxine | pH 8.0, 37°C | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.21.99.3 | Homo sapiens | - |
5-deiodinase activity | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.21.99.3 | astrocytoma cell | - |
Homo sapiens | - |
1.21.99.3 | brain cancer cell | 5-deiodinase activity | Homo sapiens | - |
1.21.99.3 | glioblastoma cell | - |
Homo sapiens | - |
1.21.99.3 | lymphoma cell | malignant | Homo sapiens | - |
1.21.99.3 | medulloblastoma cell | - |
Homo sapiens | - |
1.21.99.3 | meningioma cell | - |
Homo sapiens | - |
1.21.99.3 | oligodendroglioma cell | - |
Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.21.99.3 | additional information | - |
3,3',5,5'-tetraiodo-L-thyronine 5-deiodinase activity in brain carcinoma types | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.21.99.3 | L-thyroxine + AH2 | 5-deiodinase activity | Homo sapiens | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.21.99.3 | 37 | - |
3,3',5,5'-tetraiodo-L-thyronine 5-deiodinase activity | Homo sapiens |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.21.99.3 | 70 | - |
30 min, inactivation of 5-deiodinase | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.21.99.3 | 8 | - |
3,3',5,5'-tetraiodo-L-thyronine 5deiodinase activity | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.21.99.3 | dithiothreitol | absolutely required | Homo sapiens | |
1.21.99.3 | dithiothreitol | optimal at 50-100 mM | Homo sapiens |