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Literature summary extracted from

  • Galton, V.A.; Hiebert, A.
    Hepatic iodothyronine 5-deiodinase activity in Rana catesbeiana tadpoles at different stages of the life cycle (1987), Endocrinology, 121, 42-47.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.99.3 3,3',5'-triiodo-L-thyronine 75% inhibition at 0.01 mM; substrate inhibition Lithobates catesbeianus
1.21.99.3 3,3',5,5'-tetraiodo-L-thyronine 95% substrate inhibition at 0.001 mM Lithobates catesbeianus
1.21.99.3 3,3',5-triiodo-L-thyronine substrate inhibition, completely at 0.001 mM Lithobates catesbeianus
1.21.99.3 3,3'-diiodo-L-thyronine product inhibition, 82% at 0.001 mM Lithobates catesbeianus
1.21.99.3 3,5-diiodo-L-thyronine 75% inhibition of 3,3'-diiodo-L-thyronine formation at 0.001 mM Lithobates catesbeianus
1.21.99.3 sodium iodate 95% inhibition at 1 mM Lithobates catesbeianus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.21.99.3 0.0000036
-
 3,3',5-triiodo-L-thyronine pH 7.0 Lithobates catesbeianus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.21.99.3 microsome
-
 Lithobates catesbeianus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 Lithobates catesbeianus
-
 3,3'-diiodo-L-thyronine + iodide + A + H+ i.e. 3,3'-diiodo-L-thyronine ?
1.21.99.3 L-thyroxine + AH2 Lithobates catesbeianus 5-deiodinase activity 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 Lithobates catesbeianus in pre- and prometamorphic tadpoles, undetectable during metamorphic climax 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 Lithobates catesbeianus 5'-deiodinase activity 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 Lithobates catesbeianus in vivo after entering metamorphic climax, low 5'-deiodinase activity 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 additional information Lithobates catesbeianus enzyme activity is developmentally regulated, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.3 Lithobates catesbeianus
-
 isozyme type III
-
1.21.99.3 Lithobates catesbeianus
-
 tadpole
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.3 liver tadpole Lithobates catesbeianus
-
1.21.99.3 additional information 5'-deiodinase and 5-deiodinase activity are developmentally regulated Lithobates catesbeianus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.3 3,3',5'-triiodo-L-thyronine + AH2
-
 Lithobates catesbeianus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2
-
 Lithobates catesbeianus 3,3'-diiodo-L-thyronine + iodide + A + H+ i.e. 3,3'-diiodo-L-thyronine ?
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 best substrate Lithobates catesbeianus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 isozyme type III Lithobates catesbeianus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 5-deiodinase activity Lithobates catesbeianus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 in pre- and prometamorphic tadpoles, undetectable during metamorphic climax Lithobates catesbeianus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 low activity Lithobates catesbeianus 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 5'-deiodinase activity Lithobates catesbeianus 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 in vivo after entering metamorphic climax, low 5'-deiodinase activity Lithobates catesbeianus 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 additional information enzyme activity is developmentally regulated, overview Lithobates catesbeianus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.21.99.3 7
-
 assay at Lithobates catesbeianus