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Literature summary extracted from

  • Kaminski, Z.W.; Jezewska, M.M.
    Effect of NADH on hypoxanthine hydroxylation by native NAD+-dependent xanthine oxidoreductase of rat liver, and the possible biological role of this effect (1981), Biochem. J., 200, 597-603.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.1.4 NADH accumulation of produced NADH inhibits activity to 50% Rattus sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.1.4 hypoxanthine + NAD+ + H+ + O2- + H2O Rattus sp.
-
xanthine + NADH + H2O2
-
?
1.17.1.4 xanthine + NAD+ + H2O Rattus sp.
-
urate + NADH
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.17.1.4 Rattus sp.
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.17.1.4 to homogeneity, affinity chromatography Rattus sp.

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.1.4 liver
-
Rattus sp.
-

Storage Stability

EC Number Storage Stability Organism
1.17.1.4 -20°C, pH 8.6, 3 days Rattus sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.1.4 hypoxanthine + NAD+ + H+ + O2- + H2O
-
Rattus sp. xanthine + NADH + H2O2
-
?
1.17.1.4 xanthine + NAD+ + H2O
-
Rattus sp. urate + NADH
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.1.4 NAD+
-
Rattus sp.