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Literature summary extracted from

  • Kakimoto, Y.; Taniguchi, K.; Sano, I.
    D-beta-Aminoisobutyrate:pyruvate aminotransferase in mammalian liver and excretion of beta-aminoisobutyrate by man (1969), J. Biol. Chem., 244, 335-340.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.6.1.40 2-mercaptoethanol activation only in the presence of pyridoxal phosphate Rattus norvegicus
2.6.1.40 2-mercaptoethanol activation only in the presence of pyridoxal phosphate Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.40 hydroxylamine
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.40 0.81
-
 beta-Alanine pH 8.8, 37°C Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.40 (R)-3-amino-2-methylpropanoate + pyruvate Cavia porcellus first step in aminoisobutyrate metabolism 2-methyl-3-oxopropanoate + L-alanine
-
 ?
2.6.1.40 (R)-3-amino-2-methylpropanoate + pyruvate Homo sapiens first step in aminoisobutyrate metabolism 2-methyl-3-oxopropanoate + L-alanine
-
 ?
2.6.1.40 (R)-3-amino-2-methylpropanoate + pyruvate Rattus norvegicus first step in aminoisobutyrate metabolism 2-methyl-3-oxopropanoate + L-alanine
-
 ?
2.6.1.40 (R)-3-amino-2-methylpropanoate + pyruvate Sus scrofa first step in aminoisobutyrate metabolism 2-methyl-3-oxopropanoate + L-alanine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.40 Cavia porcellus
-
-
-
2.6.1.40 Homo sapiens
-
-
-
2.6.1.40 Rattus norvegicus
-
-
-
2.6.1.40 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.40
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.40 kidney
-
 Cavia porcellus
-
2.6.1.40 liver
-
 Cavia porcellus
-
2.6.1.40 liver
-
 Homo sapiens
-
2.6.1.40 liver
-
 Rattus norvegicus
-
2.6.1.40 liver
-
 Sus scrofa
-
2.6.1.40 additional information
-
 Rattus norvegicus
-
2.6.1.40 additional information distribution in guinea pig tissue Cavia porcellus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.40 0.093
-
 pH 8.8, 37°C Sus scrofa

Storage Stability

EC Number Storage Stability Organism
2.6.1.40 -20°C, at least 1 month Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.40 (R)-3-amino-2-methylpropanoate + glyoxylate
-
 Rattus norvegicus 2-methyl-3-oxopropanoate + glycine
-
 ?
2.6.1.40 (R)-3-amino-2-methylpropanoate + glyoxylate with 50% efficiency compared to pyruvate Sus scrofa 2-methyl-3-oxopropanoate + glycine
-
 ?
2.6.1.40 (R)-3-amino-2-methylpropanoate + pyruvate
-
 Homo sapiens 2-methyl-3-oxopropanoate + L-alanine
-
 ?
2.6.1.40 (R)-3-amino-2-methylpropanoate + pyruvate
-
 Sus scrofa 2-methyl-3-oxopropanoate + L-alanine
-
 ?
2.6.1.40 (R)-3-amino-2-methylpropanoate + pyruvate
-
 Rattus norvegicus 2-methyl-3-oxopropanoate + L-alanine i.e. methylmalonyl semialdehyde ?
2.6.1.40 (R)-3-amino-2-methylpropanoate + pyruvate best substrate among omega-amino acids, highly specific for D-isomer Cavia porcellus 2-methyl-3-oxopropanoate + L-alanine
-
 r
2.6.1.40 (R)-3-amino-2-methylpropanoate + pyruvate first step in aminoisobutyrate metabolism Cavia porcellus 2-methyl-3-oxopropanoate + L-alanine
-
 ?
2.6.1.40 (R)-3-amino-2-methylpropanoate + pyruvate first step in aminoisobutyrate metabolism Homo sapiens 2-methyl-3-oxopropanoate + L-alanine
-
 ?
2.6.1.40 (R)-3-amino-2-methylpropanoate + pyruvate first step in aminoisobutyrate metabolism Rattus norvegicus 2-methyl-3-oxopropanoate + L-alanine
-
 ?
2.6.1.40 (R)-3-amino-2-methylpropanoate + pyruvate first step in aminoisobutyrate metabolism Sus scrofa 2-methyl-3-oxopropanoate + L-alanine
-
 ?
2.6.1.40 4-aminobutanoate + pyruvate transamination at 19% the rate of (R)-3-amino-2-methylpropanoate Sus scrofa succinic semialdehyde + L-alanine
-
 ?
2.6.1.40 beta-alanine + pyruvate
-
 Rattus norvegicus malonic semialdehyde + L-alanine
-
 ?
2.6.1.40 beta-alanine + pyruvate transamination at 66% the rate of (R)-3-amino-2-methylpropanoate Sus scrofa malonic semialdehyde + L-alanine
-
 ?
2.6.1.40 DL-alpha-ethyl-beta-alanine + pyruvate transamination at 33% the rate of (R)-3-amino-2-methylpropanoate Sus scrofa 2-ethyl-3-oxopropanoate + L-alanine
-
 ?
2.6.1.40 additional information
-
 Cavia porcellus ?
-
 ?
2.6.1.40 additional information
-
 Homo sapiens ?
-
 ?
2.6.1.40 additional information no substrate: 2-oxoglutarate Rattus norvegicus ?
-
 ?
2.6.1.40 additional information no substrate: 2-oxoglutarate Sus scrofa ?
-
 ?
2.6.1.40 additional information no substrate: 5-amino-n-pentanoate, 6-aminohexanoate, DL-3-aminobutyrate, oxaloacetate Sus scrofa ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.6.1.40 37
-
 assay at Cavia porcellus
2.6.1.40 37
-
 assay at Homo sapiens
2.6.1.40 37
-
 assay at Rattus norvegicus
2.6.1.40 37
-
 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.40 9
-
-
 Sus scrofa

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.6.1.40 7.5 10.6 about half-maximal activity at pH 7.5 and pH 10.6 Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.40 pyridoxal 5'-phosphate
-
 Rattus norvegicus
2.6.1.40 pyridoxal 5'-phosphate
-
 Sus scrofa