BRENDA - Enzyme Database

Inhibition of rat liver CDPethanolamine: 1,2-diacylglycerol ethanolamine-phosphotransferase activity by ATP and pantothenic acid derivatives

Liteplo, R.G.; Sribney, M.; Can. J. Biochem. 55, 1049-1056 (1977)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.8.1
ATP
plus pantetheine: inhibition of Mn2+- and Mg2+-activated enzyme, plus CoA: inhibition of Mn2+-activated enzyme, slight stimulation of Mg2+-activated enzyme, ATP alone: inhibition of Mg2+- and Mn2+-activated enzyme
Rattus norvegicus
2.7.8.1
Ca2+
Mg2+- or Mn2+-activated enzyme
Rattus norvegicus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.8.1
additional information
-
additional information
-
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.8.1
microsome
-
Rattus norvegicus
-
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.8.1
Mg2+
Mg2+ at 20 mM or Mn2+ at 1 mM required for optimum activity
Rattus norvegicus
2.7.8.1
Mn2+
Mg2+ at 20 mM or Mn2+ at 1 mM required for optimum activity; much more effective than Mg2+
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.8.1
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.8.1
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.8.1
CDP-ethanolamine + 1,2-diacylglycerol
-
644411
Rattus norvegicus
CMP + a phosphatidylethanolamine
-
644411
Rattus norvegicus
-
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.8.1
ATP
plus pantetheine: inhibition of Mn2+- and Mg2+-activated enzyme, plus CoA: inhibition of Mn2+-activated enzyme, slight stimulation of Mg2+-activated enzyme, ATP alone: inhibition of Mg2+- and Mn2+-activated enzyme
Rattus norvegicus
2.7.8.1
Ca2+
Mg2+- or Mn2+-activated enzyme
Rattus norvegicus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.8.1
additional information
-
additional information
-
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.8.1
microsome
-
Rattus norvegicus
-
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.8.1
Mg2+
Mg2+ at 20 mM or Mn2+ at 1 mM required for optimum activity
Rattus norvegicus
2.7.8.1
Mn2+
Mg2+ at 20 mM or Mn2+ at 1 mM required for optimum activity; much more effective than Mg2+
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.8.1
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.8.1
CDP-ethanolamine + 1,2-diacylglycerol
-
644411
Rattus norvegicus
CMP + a phosphatidylethanolamine
-
644411
Rattus norvegicus
-