Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Henneberry, A.L.; Wistow, G.; McMaster, C.R.
    Cloning, genomic organization, and characterization of a human cholinephosphotransferase (2000), J. Biol. Chem., 275, 29808-29815.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.2
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.2 Mg2+ inhibitory above 10 mM, activation below Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.8.2 Mg2+ activation, 10fold more than Mn2+, preferred substrates in decreasing order, activation by Mg2+: di18:1-diacylglycerol, 16:0/22:6-diacylglycerol, 16:0/18:1-diacylglycerol, 18:0/20:4-diacylglycerol, di16:0-diacylglycerol Homo sapiens
2.7.8.2 Mn2+ activation, but much less than Mg2+, preferred substrates in decreasing order, activation by Mn2+: di10:0-diacylglycerol, 18:1/2:0-diacylglycerol, 16:0/22:6-diacylglycerol, di18:1-diacylglycerol, di16:0-diacylglycerol, di14:1-diacylglycerol, di16:1-diacylglycerol Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.8.2 39000
-
 x * 39000, hCPT1, SDS-PAGE and deduced from gene sequence Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.2 Homo sapiens Q8WUD6
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.2 CDP-choline + 1,2-diacylglycerol preferred substrates in decreasing order, activation by Mg2+: di18:1-diacylglycerol, 16:0/22:6-diacylglycerol, 16:0/18:1-diacylglycerol, 18:0/20:4-diacylglycerol, di16:0-diacylglycerol, preferred substrates in decreasing order, activation by Mn2+: di10:0-diacylglycerol, 18:1/2:0-diacylglycerol, 16:0/22:6-diacylglycerol, di18:1-diacylglycerol, di16:0-diacylglycerol, di14:1-diacylglycerol, di16:1-diacylglycerol Homo sapiens CMP + a phosphatidylcholine
-
 ?
2.7.8.2 additional information no substrates: 16:0(O)/2:0-diacylglycerol, 16:0(O)/20:4-diacylglycerol Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.8.2 ? x * 39000, hCPT1, SDS-PAGE and deduced from gene sequence Homo sapiens