EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.8.1 | - |
Homo sapiens |
2.7.8.2 | - |
Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.8.1 | Mn2+ | above 10 mM | Homo sapiens | |
2.7.8.2 | Mn2+ | inhibitory above 10 mM, activation below | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.8.1 | 0.037 | - |
CDP-choline | cosubstrate di-18:0 diacylglycerol, 20°C, pH 8.0 | Homo sapiens | |
2.7.8.1 | 0.101 | - |
CDP-ethanolamine | cosubstrate di-18:0 diacylglycerol, 20°C, pH 8.0 | Homo sapiens | |
2.7.8.2 | 0.037 | - |
CDP-choline | cosubstrate di-18:1-diacylglycerol, 20°C, pH 8.0 | Homo sapiens | |
2.7.8.2 | 0.101 | - |
CDP-ethanolamine | cosubstrate di-18:1-diacylglycerol, 20°C, pH 8.0 | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.8.1 | Mg2+ | activates, more effective on cholinephosphotransferase activity | Homo sapiens | |
2.7.8.1 | Mn2+ | activates, more effective on ethanolaminephosphotransferase activity, inhibitory above 10 mM | Homo sapiens | |
2.7.8.2 | Mg2+ | activates, acts mostly on cholinephosphotransferase activity | Homo sapiens | |
2.7.8.2 | Mn2+ | activates, acts mostly on ethanolaminephosphotransferase activity, inhibitory above 10 mM | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.7.8.1 | 46500 | - |
x * 46500, SDS-PAGE and deduced from gene sequence | Homo sapiens |
2.7.8.2 | 46500 | - |
x * 46500, hCEPT1, SDS-PAGE and deduced from gene sequence, seven membrane-spanning helices | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.8.1 | Homo sapiens | - |
dual-specificity enzyme, activity of EC 2.7.8.1 and EC 2.7.8.2 | - |
2.7.8.2 | Homo sapiens | - |
dual-specificity enzyme, activitiy of EC 2.7.8.1 and EC 2.7.8.2 | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.8.1 | CDP-choline + 1,2-diacylglycerol | preferred substrates in decreasing order: di-10:0 diacylglycerol, di-16:1 diacylglycerol, di-8:0 diacylglycerol, di-18:1 diacylglycerol, 16:0/22:6 diacylglycerol | Homo sapiens | CMP + phosphatidylcholine | - |
? | |
2.7.8.1 | CDP-ethanolamine + 1,2-diacylglycerol | preferred substrates in decreasing order: di-18:1 diacylglycerol, di-16:1 diacylglycerol, 16:0/18:1 diacylglycerol, 16:0/22:6 diacylglycerol | Homo sapiens | CMP + a phosphatidylethanolamine | - |
? | |
2.7.8.2 | CDP-choline + 1,2-diacylglycerol | preferred substrates in decreasing order: di-10:0 diacylglycerol, di-16:1 diacylglycerol, di-8:0 diacylglycerol, di-18:1 diacylglycerol, 16:0/22:6 diacylglycerol | Homo sapiens | CMP + a phosphatidylcholine | - |
? | |
2.7.8.2 | CDP-ethanolamine + 1,2-diacylglycerol | preferred substrates in decreasing order: di-18:1 diacylglycerol, di-16:1 diacylglycerol, 16:0/18:1 diacylglycerol, 16:0/22:6 diacylglycerol | Homo sapiens | CMP + phosphatidylethanolamine | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.7.8.1 | ? | x * 46500, SDS-PAGE and deduced from gene sequence | Homo sapiens |
2.7.8.2 | ? | x * 46500, hCEPT1, SDS-PAGE and deduced from gene sequence, seven membrane-spanning helices | Homo sapiens |