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Literature summary extracted from

  • O, K.M.; Siow, Y.L.; Choy, P.C.
    Hamster liver cholinephosphotransferase and ethanolaminephosphotransferase are separate enzymes (1989), Biochem. Cell Biol., 67, 680-686.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.8.1 CHAPS activates Mesocricetus auratus
2.7.8.1 octyl glucoside activates at low concentration, inhibits at higher concentration Mesocricetus auratus
2.7.8.1 taurocholate
-
 Mesocricetus auratus
2.7.8.2 Phospholipids phosphatidylcholine, phosphatidylethanolamine or lysophosphatidylethanolamine activates, lysophosphatidylcholine inhibits Mesocricetus auratus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.1 octyl glucoside activates at low concentration, inhibits at higher concentration Mesocricetus auratus
2.7.8.2 CHAPS
-
 Mesocricetus auratus
2.7.8.2 CHAPSO
-
 Mesocricetus auratus
2.7.8.2 n-octylglucoside
-
 Mesocricetus auratus
2.7.8.2 Phospholipids phosphatidylcholine, phosphatidylethanolamine or lysophosphatidylethanolamine activates, lysophosphatidylcholine inhibits Mesocricetus auratus
2.7.8.2 Triton X-100 X-200 Mesocricetus auratus
2.7.8.2 Tween-20
-
 Mesocricetus auratus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.1 microsome
-
 Mesocricetus auratus
-
-
2.7.8.2 microsome
-
 Mesocricetus auratus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.8.1 Mg2+ Mn2+ or Mg2+ required Mesocricetus auratus
2.7.8.1 Mg2+ can partially replace Mn2+ in activation Mesocricetus auratus
2.7.8.1 Mn2+ Mn2+ or Mg2+ required Mesocricetus auratus
2.7.8.1 Mn2+ much more effective than Mg2+ Mesocricetus auratus
2.7.8.2 Mg2+ absolute requirement for Mg2+ or Mn2+ Mesocricetus auratus
2.7.8.2 Mg2+ maximal activation at 10 mM Mesocricetus auratus
2.7.8.2 Mn2+ absolute requirement for Mg2+ or Mn2+ Mesocricetus auratus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.1 CDP-ethanolamine + 1,2-diacylglycerol Mesocricetus auratus
-
 CMP + a phosphatidylethanolamine
-
 r
2.7.8.1 additional information Mesocricetus auratus catalyzes the final step in synthesis of phosphatidylethanolamine ?
-
 ?
2.7.8.2 CDP-choline + sn-1,2-diacylglycerol Mesocricetus auratus final reaction in synthesis of phosphatidylcholine ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.1 Mesocricetus auratus
-
-
-
2.7.8.2 Mesocricetus auratus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.8.1 partial Mesocricetus auratus
2.7.8.2 partial Mesocricetus auratus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.1 liver
-
 Mesocricetus auratus
-
2.7.8.2 liver
-
 Mesocricetus auratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.1 CDP-ethanolamine + 1,2-diacylglycerol
-
 Mesocricetus auratus CMP + a phosphatidylethanolamine
-
 r
2.7.8.1 lysophosphatidylcholine + CMP 75% of the activity with phosphatidylethanolamine Mesocricetus auratus ?
-
 r
2.7.8.1 lysophosphatidylethanolamine + CMP 74% of the activity with phosphatidylethanolamine Mesocricetus auratus ?
-
 r
2.7.8.1 additional information catalyzes the final step in synthesis of phosphatidylethanolamine Mesocricetus auratus ?
-
 ?
2.7.8.1 phosphatidylcholine + CMP 88% of the activity with phosphatidylethanolamine Mesocricetus auratus CDP-choline + diacylglycerol
-
 r
2.7.8.2 CDP-choline + 1,2-diacylglycerol
-
 Mesocricetus auratus CMP + a phosphatidylcholine
-
 ?
2.7.8.2 CDP-choline + sn-1,2-diacylglycerol final reaction in synthesis of phosphatidylcholine Mesocricetus auratus ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.8.1 37
-
-
 Mesocricetus auratus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.7.8.1 55
-
 1 min, 90% loss of activity Mesocricetus auratus
2.7.8.2 55
-
 1 min, 90% loss of activity, whole microsomes, less than 60% loss of activity, partially purified enzyme Mesocricetus auratus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.8.1 8.5
-
 broad Mesocricetus auratus