BRENDA - Enzyme Database

Effects of Ca2+ on ethanolaminephosphotransferase and cholinephosphotransferase in rabbit platelets

Taniguchi, S.; Morikawa, S.; Hayashi, H.; Fujii, K.; Mori, H.; Fujiwara, M.; Fujiwara, M.; J. Biochem. 100, 485-491 (1986)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.8.1
Ca2+
half maximal inhibition at 0.015 mM with Mg2+ as cofactor, half maximal inhibition at 5 mM with Mn2+ as cofactor
Oryctolagus cuniculus
2.7.8.2
Ca2+
half-maximal inhibition: 0.15 mM in presence of 5 mM Mg2+, half-maximal inhibition: 5 mM in presence of 5 mM Mn2+
Oryctolagus cuniculus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.8.2
membrane
membrane of platelets
Oryctolagus cuniculus
16020
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.8.1
Co2+
enzyme requires Mg2+, Mn2+ or Co2+, maximal activity at 5 mM
Oryctolagus cuniculus
2.7.8.1
Mg2+
maximal activity at 10 mM; requires Mg2+, Mn2+ or Co2+
Oryctolagus cuniculus
2.7.8.1
Mn2+
maximal activity at: 5 mM; requires Mn2+, Mg2+ or Co2+
Oryctolagus cuniculus
2.7.8.2
Co2+
Mn2+, Mg2+ or Co2+ required, maximal activation: 10 mM
Oryctolagus cuniculus
2.7.8.2
Mg2+
maximal activation at 5 mM; Mn2+, Mg2+ or Co2+ required
Oryctolagus cuniculus
2.7.8.2
Mn2+
maximal activation: 5 mM; Mn2+, Mg2+ or Co2+ required
Oryctolagus cuniculus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.8.1
Oryctolagus cuniculus
-
-
-
2.7.8.2
Oryctolagus cuniculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.8.1
platelet
membrane
Oryctolagus cuniculus
-
2.7.8.2
platelet
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.8.1
CDP-ethanolamine + 1,2-diacylglycerol
-
644350
Oryctolagus cuniculus
CMP + a phosphatidylethanolamine
-
644350
Oryctolagus cuniculus
?
2.7.8.2
CDP-choline + 1,2-diacylglycerol
-
644350
Oryctolagus cuniculus
CMP + a phosphatidylcholine
-
644350
Oryctolagus cuniculus
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.8.1
Ca2+
half maximal inhibition at 0.015 mM with Mg2+ as cofactor, half maximal inhibition at 5 mM with Mn2+ as cofactor
Oryctolagus cuniculus
2.7.8.2
Ca2+
half-maximal inhibition: 0.15 mM in presence of 5 mM Mg2+, half-maximal inhibition: 5 mM in presence of 5 mM Mn2+
Oryctolagus cuniculus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.8.2
membrane
membrane of platelets
Oryctolagus cuniculus
16020
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.8.1
Co2+
enzyme requires Mg2+, Mn2+ or Co2+, maximal activity at 5 mM
Oryctolagus cuniculus
2.7.8.1
Mg2+
maximal activity at 10 mM; requires Mg2+, Mn2+ or Co2+
Oryctolagus cuniculus
2.7.8.1
Mn2+
maximal activity at: 5 mM; requires Mn2+, Mg2+ or Co2+
Oryctolagus cuniculus
2.7.8.2
Co2+
Mn2+, Mg2+ or Co2+ required, maximal activation: 10 mM
Oryctolagus cuniculus
2.7.8.2
Mg2+
maximal activation at 5 mM; Mn2+, Mg2+ or Co2+ required
Oryctolagus cuniculus
2.7.8.2
Mn2+
maximal activation: 5 mM; Mn2+, Mg2+ or Co2+ required
Oryctolagus cuniculus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.8.1
platelet
membrane
Oryctolagus cuniculus
-
2.7.8.2
platelet
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.8.1
CDP-ethanolamine + 1,2-diacylglycerol
-
644350
Oryctolagus cuniculus
CMP + a phosphatidylethanolamine
-
644350
Oryctolagus cuniculus
?
2.7.8.2
CDP-choline + 1,2-diacylglycerol
-
644350
Oryctolagus cuniculus
CMP + a phosphatidylcholine
-
644350
Oryctolagus cuniculus
?