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Literature summary extracted from

  • Woodard, D.S.; Lee, T.c.; Snyder, F.
    The final step in the de novo biosynthesis of platelet-activating factor. Properties of a unique CDP-choline:1-alkyl-2-acetyl-sn-glycerol choline-phosphotransferase in microsomes from the renal inner medulla of rats (1987), J. Biol. Chem., 262, 2520-2527.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.8.2 dithiothreitol dithiothreitol-insensitive enzyme Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.2 Ca2+
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.8.2 additional information
-
 additional information
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.2 microsome cytoplasmic face of microsomal vesicles Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.2 additional information Rattus norvegicus renal dithiothreitol-insensitive enzyme could be a potentially important enzyme in the regulation of systemic blood pressure ?
-
 ?
2.7.8.2 additional information Rattus norvegicus dithiothreitol-insensitive activity ?
-
 ?
2.7.8.2 additional information Rattus norvegicus final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.2 kidney inner medulla Rattus norvegicus
-
2.7.8.2 renal medulla inner medulla Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.2 CDP-choline + 1,2-diacylglycerol
-
 Rattus norvegicus CMP + a phosphatidylcholine
-
 ?
2.7.8.2 additional information dithiothreitol-insensitive enzyme prefers a lipid substrate with 16:0 or 18:1 sn-1-alkyl chains Rattus norvegicus ?
-
 ?
2.7.8.2 additional information short chain esters at the sn-2 position (acetate or propionate) are utilized Rattus norvegicus ?
-
 ?
2.7.8.2 additional information no substrate: analogs with acetamide or methoxy substituents at the sn-2-position Rattus norvegicus ?
-
 ?
2.7.8.2 additional information renal dithiothreitol-insensitive enzyme could be a potentially important enzyme in the regulation of systemic blood pressure Rattus norvegicus ?
-
 ?
2.7.8.2 additional information dithiothreitol-insensitive activity Rattus norvegicus ?
-
 ?
2.7.8.2 additional information final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway Rattus norvegicus ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.8.2 37
-
 assay at Rattus norvegicus