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Literature summary extracted from

  • Lee, T.C.; Snyder, F.
    1-Alkyl-2-acetyl-sn-glycerol cholinephosphotransferase (1992), Methods Enzymol., 209, 279-283.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.8.2 dithiothreitol slight but significant stimulation Gallus gallus
2.7.8.2 dithiothreitol slight but significant stimulation Homo sapiens
2.7.8.2 dithiothreitol slight but significant stimulation Rattus norvegicus
2.7.8.2 dithiothreitol slight but significant stimulation Oryctolagus cuniculus
2.7.8.2 dithiothreitol dithiothreitol-insensitive enzyme Gallus gallus
2.7.8.2 dithiothreitol dithiothreitol-insensitive enzyme Homo sapiens
2.7.8.2 dithiothreitol dithiothreitol-insensitive enzyme Rattus norvegicus
2.7.8.2 dithiothreitol dithiothreitol-insensitive enzyme Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.2 Ca2+
-
 Oryctolagus cuniculus
2.7.8.2 Ca2+ above 0.01 mM Rattus norvegicus
2.7.8.2 ethanol 2.5% Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.2 microsome
-
 Gallus gallus
-
-
2.7.8.2 microsome
-
 Rattus norvegicus
-
-
2.7.8.2 microsome
-
 Oryctolagus cuniculus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.8.2 Mg2+
-
 Homo sapiens
2.7.8.2 Mg2+ required Rattus norvegicus
2.7.8.2 Mg2+ required Oryctolagus cuniculus
2.7.8.2 Mg2+ maximal activation at 10-20 mM Rattus norvegicus
2.7.8.2 Mn2+
-
 Homo sapiens
2.7.8.2 Mn2+ can partially replace Mg2+ in activation Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.2 CDP-choline + sn-1,2-diacylglycerol Gallus gallus dithiothreitol-sensitive activity ?
-
 ?
2.7.8.2 CDP-choline + sn-1,2-diacylglycerol Homo sapiens dithiothreitol-sensitive activity ?
-
 ?
2.7.8.2 CDP-choline + sn-1,2-diacylglycerol Rattus norvegicus dithiothreitol-sensitive activity ?
-
 ?
2.7.8.2 CDP-choline + sn-1,2-diacylglycerol Oryctolagus cuniculus dithiothreitol-sensitive activity ?
-
 ?
2.7.8.2 CDP-choline + sn-1,2-diacylglycerol Gallus gallus final reaction in synthesis of phosphatidylcholine ?
-
 ?
2.7.8.2 CDP-choline + sn-1,2-diacylglycerol Homo sapiens final reaction in synthesis of phosphatidylcholine ?
-
 ?
2.7.8.2 CDP-choline + sn-1,2-diacylglycerol Rattus norvegicus final reaction in synthesis of phosphatidylcholine ?
-
 ?
2.7.8.2 CDP-choline + sn-1,2-diacylglycerol Oryctolagus cuniculus final reaction in synthesis of phosphatidylcholine ?
-
 ?
2.7.8.2 additional information Gallus gallus dithiothreitol-insensitive activity ?
-
 ?
2.7.8.2 additional information Homo sapiens dithiothreitol-insensitive activity ?
-
 ?
2.7.8.2 additional information Rattus norvegicus dithiothreitol-insensitive activity ?
-
 ?
2.7.8.2 additional information Oryctolagus cuniculus dithiothreitol-insensitive activity ?
-
 ?
2.7.8.2 additional information Gallus gallus final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway ?
-
 ?
2.7.8.2 additional information Homo sapiens final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway ?
-
 ?
2.7.8.2 additional information Rattus norvegicus final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway ?
-
 ?
2.7.8.2 additional information Oryctolagus cuniculus final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.2 Gallus gallus
-
-
-
2.7.8.2 Homo sapiens
-
-
-
2.7.8.2 Oryctolagus cuniculus
-
-
-
2.7.8.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.2 brain
-
 Rattus norvegicus
-
2.7.8.2 brain
-
 Oryctolagus cuniculus
-
2.7.8.2 neutrophil
-
 Homo sapiens
-
2.7.8.2 retina
-
 Gallus gallus
-
2.7.8.2 spleen
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.2 CDP-choline + 1,2-diacylglycerol
-
 Gallus gallus CMP + a phosphatidylcholine
-
 ?
2.7.8.2 CDP-choline + 1,2-diacylglycerol
-
 Homo sapiens CMP + a phosphatidylcholine
-
 ?
2.7.8.2 CDP-choline + 1,2-diacylglycerol
-
 Rattus norvegicus CMP + a phosphatidylcholine
-
 ?
2.7.8.2 CDP-choline + 1,2-diacylglycerol
-
 Oryctolagus cuniculus CMP + a phosphatidylcholine
-
 ?
2.7.8.2 CDP-choline + 1-hexadecyl-2-acetyl-sn-glycerol
-
 Rattus norvegicus CMP + 1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine
-
 ?
2.7.8.2 CDP-choline + sn-1,2-diacylglycerol dithiothreitol-sensitive activity Gallus gallus ?
-
 ?
2.7.8.2 CDP-choline + sn-1,2-diacylglycerol dithiothreitol-sensitive activity Homo sapiens ?
-
 ?
2.7.8.2 CDP-choline + sn-1,2-diacylglycerol dithiothreitol-sensitive activity Rattus norvegicus ?
-
 ?
2.7.8.2 CDP-choline + sn-1,2-diacylglycerol dithiothreitol-sensitive activity Oryctolagus cuniculus ?
-
 ?
2.7.8.2 CDP-choline + sn-1,2-diacylglycerol final reaction in synthesis of phosphatidylcholine Gallus gallus ?
-
 ?
2.7.8.2 CDP-choline + sn-1,2-diacylglycerol final reaction in synthesis of phosphatidylcholine Homo sapiens ?
-
 ?
2.7.8.2 CDP-choline + sn-1,2-diacylglycerol final reaction in synthesis of phosphatidylcholine Rattus norvegicus ?
-
 ?
2.7.8.2 CDP-choline + sn-1,2-diacylglycerol final reaction in synthesis of phosphatidylcholine Oryctolagus cuniculus ?
-
 ?
2.7.8.2 additional information
-
 Gallus gallus ?
-
 ?
2.7.8.2 additional information higher activity with 16:0 and 18:1 substrates than with 18:0 substrates Rattus norvegicus ?
-
 ?
2.7.8.2 additional information dithiothreitol-insensitive activity Gallus gallus ?
-
 ?
2.7.8.2 additional information dithiothreitol-insensitive activity Homo sapiens ?
-
 ?
2.7.8.2 additional information dithiothreitol-insensitive activity Rattus norvegicus ?
-
 ?
2.7.8.2 additional information dithiothreitol-insensitive activity Oryctolagus cuniculus ?
-
 ?
2.7.8.2 additional information final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway Gallus gallus ?
-
 ?
2.7.8.2 additional information final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway Homo sapiens ?
-
 ?
2.7.8.2 additional information final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway Rattus norvegicus ?
-
 ?
2.7.8.2 additional information final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway Oryctolagus cuniculus ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.8.2 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.8.2 8
-
-
 Rattus norvegicus