EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.8.1 | bovine serum albumin | 1 mg/ml, 2fold increase of activity | Rattus norvegicus | |
2.7.8.1 | EGTA | stimulates | Rattus norvegicus | |
2.7.8.1 | pospholipase C | 10 min, 23°C, 26% stimulation | Rattus norvegicus | |
2.7.8.2 | EGTA | 0.5 mM, stimulates | Rattus norvegicus | |
2.7.8.2 | ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid | stimulates | Rattus norvegicus | |
2.7.8.2 | Phospholipase C | 23°C, 10 min, slight stimulation | Rattus norvegicus |
EC Number | General Stability | Organism |
---|---|---|
2.7.8.1 | trypsin, 70%, 0.9 min, activity remains stable | Rattus norvegicus |
2.7.8.2 | freezing and thawing the microsomal preparation 5times destroys activity by 50% | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.8.1 | acetone | - |
Rattus norvegicus | |
2.7.8.1 | Ca2+ | CaCl2 | Rattus norvegicus | |
2.7.8.1 | CDP | - |
Rattus norvegicus | |
2.7.8.1 | CDP-choline | - |
Rattus norvegicus | |
2.7.8.1 | CMP | - |
Rattus norvegicus | |
2.7.8.1 | CTP | - |
Rattus norvegicus | |
2.7.8.1 | dioxane | - |
Rattus norvegicus | |
2.7.8.1 | dithiothreitol | - |
Rattus norvegicus | |
2.7.8.1 | methanol | - |
Rattus norvegicus | |
2.7.8.1 | palmitoyl-CoA | - |
Rattus norvegicus | |
2.7.8.1 | Triton WR 1339 | - |
Rattus norvegicus | |
2.7.8.1 | Tween 20 | - |
Rattus norvegicus | |
2.7.8.2 | 1-butanol | - |
Rattus norvegicus | |
2.7.8.2 | acetone | - |
Rattus norvegicus | |
2.7.8.2 | Ca2+ | - |
Rattus norvegicus | |
2.7.8.2 | CDP | - |
Rattus norvegicus | |
2.7.8.2 | CDPethanolamine | - |
Rattus norvegicus | |
2.7.8.2 | dithiothreitol | - |
Rattus norvegicus | |
2.7.8.2 | methanol | - |
Rattus norvegicus | |
2.7.8.2 | palmitoyl-CoA | - |
Rattus norvegicus | |
2.7.8.2 | Triton X-100 | WR 1339; X-100 | Rattus norvegicus | |
2.7.8.2 | Trypsin | - |
Rattus norvegicus | |
2.7.8.2 | Tween-20 | - |
Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.8.1 | 0.0118 | - |
1,2-dioleoylglycerol | 23°C, pH 8.5 | Rattus norvegicus | |
2.7.8.1 | 0.0183 | - |
CDP-ethanolamine | cosubstrate 1,2-dioleoyl-sn-glycerol | Rattus norvegicus | |
2.7.8.2 | additional information | - |
additional information | - |
Rattus norvegicus | |
2.7.8.2 | 0.0057 | - |
didodecanoylglycerol | 23°C, pH 8.5 | Rattus norvegicus | |
2.7.8.2 | 0.0141 | - |
didecanoylglycerol | 23°C, pH 8.5 | Rattus norvegicus | |
2.7.8.2 | 0.0239 | - |
CDP-choline | cosubstrate 1,2-dioleoyl-sn-glycerol, 23°C, pH 8.5 | Rattus norvegicus | |
2.7.8.2 | 0.0314 | - |
dihexadecanoylglycerol | 23°C, pH 8.5 | Rattus norvegicus | |
2.7.8.2 | 0.0405 | - |
bacterial 1,2-diacyl-sn-glycerol | 23°C, pH 8.5 | Rattus norvegicus | |
2.7.8.2 | 0.0501 | - |
dioctadecenoylglycerol | 23°C, pH 8.5 | Rattus norvegicus | |
2.7.8.2 | 0.0509 | - |
1,2-dioleoyl-sn-glycerol | 23°C, pH 8.5 | Rattus norvegicus | |
2.7.8.2 | 0.0681 | - |
dihexanoylglycerol | 23°C, pH 8.5 | Rattus norvegicus | |
2.7.8.2 | 0.118 | - |
dimyristoyl-sn-glycerol | 23°C, pH 8.5 | Rattus norvegicus | |
2.7.8.2 | 0.125 | 0.126 | 1-stearoyl-2-oleoyl-sn-glycerol | 23°C, pH 8.5 | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.8.1 | microsome | - |
Rattus norvegicus | - |
- |
2.7.8.2 | microsome | - |
Rattus norvegicus | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.8.1 | Mg2+ | Mn2+ or Mg2+ required | Rattus norvegicus | |
2.7.8.1 | Mg2+ | completely dependent on MgCl2 | Rattus norvegicus | |
2.7.8.1 | Mn2+ | Mn2+ or Mg2+ required | Rattus norvegicus | |
2.7.8.1 | Mn2+ | much more effective than Mg2+ | Rattus norvegicus | |
2.7.8.2 | Mg2+ | required | Rattus norvegicus | |
2.7.8.2 | Mn2+ | can partially replace Mg2+ in activation | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.8.1 | Rattus norvegicus | - |
- |
- |
2.7.8.2 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.8.1 | adipocyte | - |
Rattus norvegicus | - |
2.7.8.1 | brain | - |
Rattus norvegicus | - |
2.7.8.1 | liver | - |
Rattus norvegicus | - |
2.7.8.1 | mucosa | of intestine | Rattus norvegicus | - |
2.7.8.2 | adipocyte | - |
Rattus norvegicus | - |
2.7.8.2 | brain | - |
Rattus norvegicus | - |
2.7.8.2 | liver | - |
Rattus norvegicus | - |
2.7.8.2 | lung | fetal | Rattus norvegicus | - |
2.7.8.2 | mucosa | of intestine | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.8.1 | CDP-ethanolamine + 1,2-diacylglycerol | - |
Rattus norvegicus | CMP + a phosphatidylethanolamine | - |
? | |
2.7.8.1 | CDP-ethanolamine + 1,2-dioleoylglycerol | highest activity | Rattus norvegicus | CMP + dioleoylphosphatidylethanolamine | - |
? | |
2.7.8.1 | CDP-ethanolamine + 1-stearoyl-2-oleoylglycerol | - |
Rattus norvegicus | CMP + 1-stearoyl-2-oleoylphosphatidylethanolamine | - |
? | |
2.7.8.1 | additional information | 1,2-diacylglycerols containing fatty acids 6, 12 and 14 carbons in length are no substrates | Rattus norvegicus | ? | - |
? | |
2.7.8.2 | CDP-choline + 1,2-diacylglycerol | - |
Rattus norvegicus | CMP + a phosphatidylcholine | - |
? | |
2.7.8.2 | CDP-choline + 1,2-dioleoyl-sn-glycerol | - |
Rattus norvegicus | CMP + 1,2-dioleoyl-sn-glycero-3-phosphocholine | - |
? | |
2.7.8.2 | CDP-choline + 1-stearoyl-2-oleoyl-sn-glycerol | - |
Rattus norvegicus | CMP + 1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine | - |
? | |
2.7.8.2 | CDP-choline + bacterial 1,2-diacyl-sn-glycerol | - |
Rattus norvegicus | CMP + phosphatidylethanolamine | - |
? | |
2.7.8.2 | CDP-choline + didecanoylglycerol | - |
Rattus norvegicus | CMP + didecanoylglycerophosphocholine | - |
? | |
2.7.8.2 | CDP-choline + didodecanoylglycerol | - |
Rattus norvegicus | CMP + didodecanoylglycerophosphocholine | - |
? | |
2.7.8.2 | CDP-choline + dihexanoylglycerol | - |
Rattus norvegicus | CMP + dihexanoylglycerophosphocholine | - |
? | |
2.7.8.2 | CDP-choline + dimyristoyl-sn-glycerol | - |
Rattus norvegicus | CMP + dimyristoyl-sn-glycerophosphocholine | - |
? | |
2.7.8.2 | additional information | specificity overview | Rattus norvegicus | ? | - |
? | |
2.7.8.2 | additional information | no substrate: 1,3-diC18:1-glycerol ether | Rattus norvegicus | ? | - |
? | |
2.7.8.2 | additional information | no substrate: 1,2-diC18:1-glycerol ether | Rattus norvegicus | ? | - |
? | |
2.7.8.2 | additional information | substrates are 1,2-diacylglycerols containing fatty acids 6, 12 and 14 carbons in length | Rattus norvegicus | ? | - |
? |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.8.1 | 37 | - |
stable for 19 min, heating of microsomes | Rattus norvegicus |
2.7.8.1 | 49 | - |
4 min, more than 50% loss of activity | Rattus norvegicus |
2.7.8.2 | 37 | - |
19 min, stable, microsomal preparation | Rattus norvegicus |
2.7.8.2 | 49 | - |
15 min, 50% loss of activity, microsomal preparation | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.8.1 | 8.5 | 9.3 | - |
Rattus norvegicus |
2.7.8.2 | 8.5 | 9.3 | - |
Rattus norvegicus |