BRENDA - Enzyme Database

Purification and properties of phosphatidylglycerophosphate synthetase from mammalian liver mitochondria

McMurray, W.C.; Jarvis, E.C.; Can. J. Biochem. 56, 414-419 (1978)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.8.5
phosphatidylethanolamine
stimulates, no stimulation by other diacylglycerophosphatides or lysophosphatides
Sus scrofa
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.8.5
Cd2+
strong inhibition at concentrations above 0.5 mM in presence of Mg2+
Sus scrofa
2.7.8.5
Co2+
Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration
Sus scrofa
2.7.8.5
Cu2+
strong inhibition at concentrations above 0.5 mM in presence of Mg2+
Sus scrofa
2.7.8.5
Hg2+
strong inhibition at concentrations above 0.5 mM in presence of Mg2+
Sus scrofa
2.7.8.5
Mg2+
Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration
Sus scrofa
2.7.8.5
Zn2+
strong inhibition at concentrations above 0.5 mM in presence of Mg2+
Sus scrofa
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.8.5
mitochondrion
membrane
Rattus norvegicus
5739
-
2.7.8.5
mitochondrion
membrane
Sus scrofa
5739
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.8.5
Ba2+
cation requirement is relatively nonspecific, Mg2+, Ba2+ or Ca2+ provides maximal activation in the 10 mM range, Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration
Sus scrofa
2.7.8.5
Ca2+
cation requirement is relatively nonspecific, Mg2+, Ba2+ or Ca2+ provide maximal activation in the 10 mM range, Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration
Sus scrofa
2.7.8.5
Co2+
cation requirement is relatively nonspecific, Mg2+, Ba2+ or Ca2+ provides maximal activation in the 10 mM range, Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration
Sus scrofa
2.7.8.5
Mg2+
cation requirement is relatively nonspecific, Mg2+, Ba2+ or Ca2+ provide maximal activation in the 10 mM range, Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration
Sus scrofa
2.7.8.5
Mn2+
cation requirement is relatively nonspecific, Mg2+, Ba2+ or Ca2+ provides maximal activation in the 10 mM range, Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration
Sus scrofa
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.8.5
Rattus norvegicus
-
-
-
2.7.8.5
Sus scrofa
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.8.5
liver
-
Sus scrofa
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.7.8.5
additional information
-
-
Sus scrofa
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.8.5
CDP-diacylglycerol + sn-glycero-3-phosphate
-
644293
Rattus norvegicus
CMP + phosphatidylglycerophosphate
-
644293
Rattus norvegicus
?
2.7.8.5
CDP-diacylglycerol + sn-glycero-3-phosphate
-
644293
Sus scrofa
CMP + phosphatidylglycerophosphate
-
644293
Sus scrofa
?
Temperature Range [°C]
EC Number
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
2.7.8.5
37
-
assay at
Sus scrofa
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.8.5
phosphatidylethanolamine
stimulates, no stimulation by other diacylglycerophosphatides or lysophosphatides
Sus scrofa
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.8.5
Cd2+
strong inhibition at concentrations above 0.5 mM in presence of Mg2+
Sus scrofa
2.7.8.5
Co2+
Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration
Sus scrofa
2.7.8.5
Cu2+
strong inhibition at concentrations above 0.5 mM in presence of Mg2+
Sus scrofa
2.7.8.5
Hg2+
strong inhibition at concentrations above 0.5 mM in presence of Mg2+
Sus scrofa
2.7.8.5
Mg2+
Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration
Sus scrofa
2.7.8.5
Zn2+
strong inhibition at concentrations above 0.5 mM in presence of Mg2+
Sus scrofa
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.8.5
mitochondrion
membrane
Rattus norvegicus
5739
-
2.7.8.5
mitochondrion
membrane
Sus scrofa
5739
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.8.5
Ba2+
cation requirement is relatively nonspecific, Mg2+, Ba2+ or Ca2+ provides maximal activation in the 10 mM range, Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration
Sus scrofa
2.7.8.5
Ca2+
cation requirement is relatively nonspecific, Mg2+, Ba2+ or Ca2+ provide maximal activation in the 10 mM range, Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration
Sus scrofa
2.7.8.5
Co2+
cation requirement is relatively nonspecific, Mg2+, Ba2+ or Ca2+ provides maximal activation in the 10 mM range, Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration
Sus scrofa
2.7.8.5
Mg2+
cation requirement is relatively nonspecific, Mg2+, Ba2+ or Ca2+ provide maximal activation in the 10 mM range, Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration
Sus scrofa
2.7.8.5
Mn2+
cation requirement is relatively nonspecific, Mg2+, Ba2+ or Ca2+ provides maximal activation in the 10 mM range, Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration
Sus scrofa
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.8.5
liver
-
Sus scrofa
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.7.8.5
additional information
-
-
Sus scrofa
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.8.5
CDP-diacylglycerol + sn-glycero-3-phosphate
-
644293
Rattus norvegicus
CMP + phosphatidylglycerophosphate
-
644293
Rattus norvegicus
?
2.7.8.5
CDP-diacylglycerol + sn-glycero-3-phosphate
-
644293
Sus scrofa
CMP + phosphatidylglycerophosphate
-
644293
Sus scrofa
?
Temperature Range [°C] (protein specific)
EC Number
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
2.7.8.5
37
-
assay at
Sus scrofa