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Literature summary extracted from

  • Kishimoto, A.; Kajikawa, N.; Tabuchi, H.; Shiota, M.; Nishizuka, Y.
    Calcium-dependent neutral proteases, widespread occurence of a species of protease active at lower concentrations of calcium (1981), J. Biochem., 90, 889-892.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.52 E-64 0.05 mg/ml, complete inhibition Rattus norvegicus
3.4.22.52 leupeptin 0.05 mg/ml, complete inhibition Rattus norvegicus
3.4.22.53 E-64 0.05 mg/ml, complete inhibition Rattus norvegicus
3.4.22.53 leupeptin 0.05 mg/ml, complete inhibition Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.22.52 Ca2+ half-maximal activity at 0.02 mM, maximal activity at 0.1 mM Rattus norvegicus
3.4.22.52 Mn2+ 0.1 mM, less than 10% as active as Ca2+ Rattus norvegicus
3.4.22.52 Sr2+ 0.1 mM, less than 10% as active as Ca2+ Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.52 88000
-
 gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.52 Rattus norvegicus
-
-
-
3.4.22.53 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.52 brain
-
 Rattus norvegicus
-
3.4.22.52 cardiac muscle
-
 Rattus norvegicus
-
3.4.22.52 kidney
-
 Rattus norvegicus
-
3.4.22.52 skeletal muscle
-
 Rattus norvegicus
-
3.4.22.53 adipose tissue
-
 Rattus norvegicus
-
3.4.22.53 brain
-
 Rattus norvegicus
-
3.4.22.53 cardiac muscle
-
 Rattus norvegicus
-
3.4.22.53 kidney
-
 Rattus norvegicus
-
3.4.22.53 liver
-
 Rattus norvegicus
-
3.4.22.53 lung
-
 Rattus norvegicus
-
3.4.22.53 skeletal muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.52 casein + H2O
-
 Rattus norvegicus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.52 7.5 8
-
 Rattus norvegicus
3.4.22.53 7.5 8
-
 Rattus norvegicus