BRENDA - Enzyme Database

Substrate specificity of a dicarboxyl-CoA: dicarboxylic acid coenzyme A transferase from rat liver mitochondria

Deana, R.; Biochem. Int. 26, 767-773 (1992)

Data extracted from this reference:

KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.8.3.13
0.07
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate glutarate
Rattus norvegicus
2.8.3.13
0.07
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate adipate
Rattus norvegicus
2.8.3.13
0.11
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate succinate
Rattus norvegicus
2.8.3.13
0.13
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate glutarate
Rattus norvegicus
2.8.3.13
0.15
-
succinyl-CoA
pH 7.8, 30°C, cosubstrate glutarate
Rattus norvegicus
2.8.3.13
0.16
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
2.8.3.13
0.18
-
3-hydroxy-3-methylglutaryl-CoA
pH 7.8, 30°C, cosubstrate adipate, reverse reaction
Rattus norvegicus
2.8.3.13
0.18
-
Glutarate
pH 7.8, 30°C, cosubstrate adipylCoA
Rattus norvegicus
2.8.3.13
0.18
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate succinate
Rattus norvegicus
2.8.3.13
0.26
-
Glutarate
pH 7.8, 30°C, cosubstrate malonylCoA
Rattus norvegicus
2.8.3.13
0.26
-
succinyl-CoA
pH 7.8, 30°C, cosubstrate adipate
Rattus norvegicus
2.8.3.13
0.27
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate malonate
Rattus norvegicus
2.8.3.13
0.28
-
succinyl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
2.8.3.13
0.33
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate adipate
Rattus norvegicus
2.8.3.13
0.38
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate malonate
Rattus norvegicus
2.8.3.13
0.39
-
3-hydroxy-3-methylglutaryl-CoA
pH 7.8, 30°C, cosubstrate succinate or glutarate, reverse reaction
Rattus norvegicus
2.8.3.13
0.39
-
adipate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA , reverse reaction
Rattus norvegicus
2.8.3.13
0.4
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate
Rattus norvegicus
2.8.3.13
0.45
-
Glutarate
pH 7.8, 30°C, cosubstrate succinylCoA
Rattus norvegicus
2.8.3.13
0.45
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate
Rattus norvegicus
2.8.3.13
0.5
-
Glutarate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA
Rattus norvegicus
2.8.3.13
0.5
-
succinate
pH 7.8, 30°C, cosubstrate glutarylCoA
Rattus norvegicus
2.8.3.13
0.52
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
2.8.3.13
0.55
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate succinate
Rattus norvegicus
2.8.3.13
0.62
-
3-hydroxy-3-methylglutaryl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate, reverse reaction
Rattus norvegicus
2.8.3.13
0.65
-
methylmalonyl-CoA
pH 7.8, 30°C, cosubstrate malonate
Rattus norvegicus
2.8.3.13
0.68
-
succinate
pH 7.8, 30°C, cosubstrate malonylCoA
Rattus norvegicus
2.8.3.13
0.7
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate
Rattus norvegicus
2.8.3.13
0.72
-
adipate
pH 7.8, 30°C, cosubstrate glutaryl-CoA
Rattus norvegicus
2.8.3.13
0.72
-
methylmalonyl-CoA
pH 7.8, 30°C, cosubstrate glutarate or adipate
Rattus norvegicus
2.8.3.13
0.73
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
2.8.3.13
0.74
-
methylmalonyl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
2.8.3.13
0.75
-
succinylCoA
pH 7.8, 30°C, cosubstrate malonate
Rattus norvegicus
2.8.3.13
0.76
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate adipyl-CoA
Rattus norvegicus
2.8.3.13
0.83
-
adipate
pH 7.8, 30°C, cosubstrate malonylCoA
Rattus norvegicus
2.8.3.13
0.83
-
succinyl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate
Rattus norvegicus
2.8.3.13
0.84
-
Glutarate
pH 7.8, 30°C, cosubstrate methylmalonylCoA
Rattus norvegicus
2.8.3.13
0.87
-
methylmalonyl-CoA
pH 7.8, 30°C, cosubstrate succinate
Rattus norvegicus
2.8.3.13
0.88
-
succinate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA, reverse reaction
Rattus norvegicus
2.8.3.13
0.95
-
succinate
pH 7.8, 30°C, cosubstrate adipyl-CoA
Rattus norvegicus
2.8.3.13
1.01
-
malonate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA , reverse reaction
Rattus norvegicus
2.8.3.13
1.2
-
succinate
pH 7.8, 30°C, cosubstrate methylmalonyl-CoA
Rattus norvegicus
2.8.3.13
1.25
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate glutaryl-CoA
Rattus norvegicus
2.8.3.13
1.32
-
adipate
pH 7.8, 30°C, cosubstrate succinylCoA
Rattus norvegicus
2.8.3.13
1.42
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate succinyl-CoA
Rattus norvegicus
2.8.3.13
1.51
-
adipate
pH 7.8, 30°C, cosubstrate methylmalonyl-CoA
Rattus norvegicus
2.8.3.13
1.55
-
malonate
pH 7.8, 30°C, cosubstrate glutaryl-CoA
Rattus norvegicus
2.8.3.13
1.63
-
malonate
pH 7.8, 30°C, cosubstrate succinyl-CoA or methylmalonyl-CoA
Rattus norvegicus
2.8.3.13
1.71
-
malonate
pH 7.8, 30°C, cosubstrate adipyl-CoA
Rattus norvegicus
2.8.3.13
1.8
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate malonyl-CoA
Rattus norvegicus
2.8.3.13
1.95
-
methylmalonate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA, reverse reaction
Rattus norvegicus
2.8.3.13
2.2
-
methylmalonate
pH 7.8, 30°C, cosubstrate malonylCoA
Rattus norvegicus
2.8.3.13
2.33
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate methylmalonyl-CoA
Rattus norvegicus
2.8.3.13
2.44
-
methylmalonate
pH 7.8, 30°C, cosubstrate glutaryl-CoA
Rattus norvegicus
2.8.3.13
2.7
-
methylmalonate
pH 7.8, 30°C, cosubstrate succinyl-CoA
Rattus norvegicus
2.8.3.13
3.05
-
methylmalonate
pH 7.8, 30°C, cosubstrate adipyl-CoA
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.8.3.13
mitochondrion
-
Rattus norvegicus
5739
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.3.13
succinyl-CoA + 3-hydroxy-3-methylglutarate
Rattus norvegicus
involved in regulation of the tricarboxylic acid cycle rate and ketogenesis
succinate + 3-hydroxy-3-methylglutaryl-CoA
-
Rattus norvegicus
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.8.3.13
Rattus norvegicus
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
2.8.3.13
-
Rattus norvegicus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.3.13
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.3.13
3-hydroxy-3-methylglutaryl-CoA + adipate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + adipyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
3-hydroxy-3-methylglutaryl-CoA + glutarate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + glutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
3-hydroxy-3-methylglutaryl-CoA + malonate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + malonyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
3-hydroxy-3-methylglutaryl-CoA + methylmalonate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
3-hydroxy-3-methylglutaryl-CoA + succinate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + succinyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
adipyl-CoA + 3-hydroxy-3-methylglutarate
-
643834
Rattus norvegicus
adipate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
adipyl-CoA + 3-hydroxy-3-methylglutarate
adipyl-CoA shows highest apparent affinty, forward reaction at 64%, reverse reaction at 32% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
adipate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
adipyl-CoA + glutarate
forward reaction at 82%, reverse reaction at 68% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
adipate + glutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
adipyl-CoA + malonate
forward reaction at 40%, reverse reaction at 43% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
adipate + malonyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
adipyl-CoA + methylmalonate
poor substrate, succinyl-CoA, glutaryl-CoA, malonyl-CoA or 3-hydroxy-3-methylglutaryl-CoA can replace adipyl-CoA
643834
Rattus norvegicus
adipate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
adipyl-CoA + succinate
best substrates, reverse reaction at 38% the rate of forward reaction
643834
Rattus norvegicus
adipate + succinyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
glutaryl-CoA + 3-hydroxy-3-methylglutarate
forward and reverse reaction at 50% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
glutarate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
glutaryl-CoA + adipate
-
643834
Rattus norvegicus
glutarate + adipyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
glutaryl-CoA + malonate
forward reaction at 33%, reverse reaction at 41% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
glutarate + malonyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
glutaryl-CoA + methylmalonate
-
643834
Rattus norvegicus
glutarate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
glutaryl-CoA + succinate
-
643834
Rattus norvegicus
glutarate + succinyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
malonyl-CoA + 3-hydroxy-3-methylglutarate
forward reaction at 34%, reverse reaction at 23% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
malonate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
malonyl-CoA + adipate
-
643834
Rattus norvegicus
malonate + adipyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
malonyl-CoA + glutarate
-
643834
Rattus norvegicus
malonate + glutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
malonyl-CoA + methylmalonate
-
643834
Rattus norvegicus
malonate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
malonyl-CoA + succinate
-
643834
Rattus norvegicus
malonate + succinyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
methylmalonyl-CoA + 3-hydroxy-3-methylglutarate
-
643834
Rattus norvegicus
methylmalonate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
methylmalonyl-CoA + adipate
-
643834
Rattus norvegicus
methylmalonate + adipyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
methylmalonyl-CoA + glutarate
-
643834
Rattus norvegicus
methylmalonate + glutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
methylmalonyl-CoA + malonate
-
643834
Rattus norvegicus
methylmalonate + malonyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
methylmalonyl-CoA + succinate
-
643834
Rattus norvegicus
methylmalonate + succinyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
succinyl-CoA + 3-hydroxy-3-methylglutarate
-
643834
Rattus norvegicus
succinate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
succinyl-CoA + 3-hydroxy-3-methylglutarate
involved in regulation of the tricarboxylic acid cycle rate and ketogenesis
643834
Rattus norvegicus
succinate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
succinyl-CoA + adipate
-
643834
Rattus norvegicus
succinate + adipyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
succinyl-CoA + glutarate
forward reaction at 58%, reverse reaction at 55% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
succinate + glutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
succinyl-CoA + malonate
forward reaction at 29%, reverse reaction at 22% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
succinate + malonyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
succinyl-CoA + methylmalonate
-
643834
Rattus norvegicus
succinate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.8.3.13
0.07
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate glutarate
Rattus norvegicus
2.8.3.13
0.07
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate adipate
Rattus norvegicus
2.8.3.13
0.11
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate succinate
Rattus norvegicus
2.8.3.13
0.13
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate glutarate
Rattus norvegicus
2.8.3.13
0.15
-
succinyl-CoA
pH 7.8, 30°C, cosubstrate glutarate
Rattus norvegicus
2.8.3.13
0.16
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
2.8.3.13
0.18
-
3-hydroxy-3-methylglutaryl-CoA
pH 7.8, 30°C, cosubstrate adipate, reverse reaction
Rattus norvegicus
2.8.3.13
0.18
-
Glutarate
pH 7.8, 30°C, cosubstrate adipylCoA
Rattus norvegicus
2.8.3.13
0.18
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate succinate
Rattus norvegicus
2.8.3.13
0.26
-
Glutarate
pH 7.8, 30°C, cosubstrate malonylCoA
Rattus norvegicus
2.8.3.13
0.26
-
succinyl-CoA
pH 7.8, 30°C, cosubstrate adipate
Rattus norvegicus
2.8.3.13
0.27
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate malonate
Rattus norvegicus
2.8.3.13
0.28
-
succinyl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
2.8.3.13
0.33
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate adipate
Rattus norvegicus
2.8.3.13
0.38
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate malonate
Rattus norvegicus
2.8.3.13
0.39
-
3-hydroxy-3-methylglutaryl-CoA
pH 7.8, 30°C, cosubstrate succinate or glutarate, reverse reaction
Rattus norvegicus
2.8.3.13
0.39
-
adipate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA , reverse reaction
Rattus norvegicus
2.8.3.13
0.4
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate
Rattus norvegicus
2.8.3.13
0.45
-
Glutarate
pH 7.8, 30°C, cosubstrate succinylCoA
Rattus norvegicus
2.8.3.13
0.45
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate
Rattus norvegicus
2.8.3.13
0.5
-
Glutarate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA
Rattus norvegicus
2.8.3.13
0.5
-
succinate
pH 7.8, 30°C, cosubstrate glutarylCoA
Rattus norvegicus
2.8.3.13
0.52
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
2.8.3.13
0.55
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate succinate
Rattus norvegicus
2.8.3.13
0.62
-
3-hydroxy-3-methylglutaryl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate, reverse reaction
Rattus norvegicus
2.8.3.13
0.65
-
methylmalonyl-CoA
pH 7.8, 30°C, cosubstrate malonate
Rattus norvegicus
2.8.3.13
0.68
-
succinate
pH 7.8, 30°C, cosubstrate malonylCoA
Rattus norvegicus
2.8.3.13
0.7
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate
Rattus norvegicus
2.8.3.13
0.72
-
adipate
pH 7.8, 30°C, cosubstrate glutaryl-CoA
Rattus norvegicus
2.8.3.13
0.72
-
methylmalonyl-CoA
pH 7.8, 30°C, cosubstrate glutarate or adipate
Rattus norvegicus
2.8.3.13
0.73
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
2.8.3.13
0.74
-
methylmalonyl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
2.8.3.13
0.75
-
succinylCoA
pH 7.8, 30°C, cosubstrate malonate
Rattus norvegicus
2.8.3.13
0.76
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate adipyl-CoA
Rattus norvegicus
2.8.3.13
0.83
-
adipate
pH 7.8, 30°C, cosubstrate malonylCoA
Rattus norvegicus
2.8.3.13
0.83
-
succinyl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate
Rattus norvegicus
2.8.3.13
0.84
-
Glutarate
pH 7.8, 30°C, cosubstrate methylmalonylCoA
Rattus norvegicus
2.8.3.13
0.87
-
methylmalonyl-CoA
pH 7.8, 30°C, cosubstrate succinate
Rattus norvegicus
2.8.3.13
0.88
-
succinate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA, reverse reaction
Rattus norvegicus
2.8.3.13
0.95
-
succinate
pH 7.8, 30°C, cosubstrate adipyl-CoA
Rattus norvegicus
2.8.3.13
1.01
-
malonate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA , reverse reaction
Rattus norvegicus
2.8.3.13
1.2
-
succinate
pH 7.8, 30°C, cosubstrate methylmalonyl-CoA
Rattus norvegicus
2.8.3.13
1.25
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate glutaryl-CoA
Rattus norvegicus
2.8.3.13
1.32
-
adipate
pH 7.8, 30°C, cosubstrate succinylCoA
Rattus norvegicus
2.8.3.13
1.42
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate succinyl-CoA
Rattus norvegicus
2.8.3.13
1.51
-
adipate
pH 7.8, 30°C, cosubstrate methylmalonyl-CoA
Rattus norvegicus
2.8.3.13
1.55
-
malonate
pH 7.8, 30°C, cosubstrate glutaryl-CoA
Rattus norvegicus
2.8.3.13
1.63
-
malonate
pH 7.8, 30°C, cosubstrate succinyl-CoA or methylmalonyl-CoA
Rattus norvegicus
2.8.3.13
1.71
-
malonate
pH 7.8, 30°C, cosubstrate adipyl-CoA
Rattus norvegicus
2.8.3.13
1.8
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate malonyl-CoA
Rattus norvegicus
2.8.3.13
1.95
-
methylmalonate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA, reverse reaction
Rattus norvegicus
2.8.3.13
2.2
-
methylmalonate
pH 7.8, 30°C, cosubstrate malonylCoA
Rattus norvegicus
2.8.3.13
2.33
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate methylmalonyl-CoA
Rattus norvegicus
2.8.3.13
2.44
-
methylmalonate
pH 7.8, 30°C, cosubstrate glutaryl-CoA
Rattus norvegicus
2.8.3.13
2.7
-
methylmalonate
pH 7.8, 30°C, cosubstrate succinyl-CoA
Rattus norvegicus
2.8.3.13
3.05
-
methylmalonate
pH 7.8, 30°C, cosubstrate adipyl-CoA
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.8.3.13
mitochondrion
-
Rattus norvegicus
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.3.13
succinyl-CoA + 3-hydroxy-3-methylglutarate
Rattus norvegicus
involved in regulation of the tricarboxylic acid cycle rate and ketogenesis
succinate + 3-hydroxy-3-methylglutaryl-CoA
-
Rattus norvegicus
r
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.8.3.13
-
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.3.13
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.3.13
3-hydroxy-3-methylglutaryl-CoA + adipate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + adipyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
3-hydroxy-3-methylglutaryl-CoA + glutarate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + glutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
3-hydroxy-3-methylglutaryl-CoA + malonate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + malonyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
3-hydroxy-3-methylglutaryl-CoA + methylmalonate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
3-hydroxy-3-methylglutaryl-CoA + succinate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + succinyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
adipyl-CoA + 3-hydroxy-3-methylglutarate
-
643834
Rattus norvegicus
adipate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
adipyl-CoA + 3-hydroxy-3-methylglutarate
adipyl-CoA shows highest apparent affinty, forward reaction at 64%, reverse reaction at 32% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
adipate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
adipyl-CoA + glutarate
forward reaction at 82%, reverse reaction at 68% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
adipate + glutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
adipyl-CoA + malonate
forward reaction at 40%, reverse reaction at 43% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
adipate + malonyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
adipyl-CoA + methylmalonate
poor substrate, succinyl-CoA, glutaryl-CoA, malonyl-CoA or 3-hydroxy-3-methylglutaryl-CoA can replace adipyl-CoA
643834
Rattus norvegicus
adipate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
adipyl-CoA + succinate
best substrates, reverse reaction at 38% the rate of forward reaction
643834
Rattus norvegicus
adipate + succinyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
glutaryl-CoA + 3-hydroxy-3-methylglutarate
forward and reverse reaction at 50% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
glutarate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
glutaryl-CoA + adipate
-
643834
Rattus norvegicus
glutarate + adipyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
glutaryl-CoA + malonate
forward reaction at 33%, reverse reaction at 41% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
glutarate + malonyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
glutaryl-CoA + methylmalonate
-
643834
Rattus norvegicus
glutarate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
glutaryl-CoA + succinate
-
643834
Rattus norvegicus
glutarate + succinyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
malonyl-CoA + 3-hydroxy-3-methylglutarate
forward reaction at 34%, reverse reaction at 23% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
malonate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
malonyl-CoA + adipate
-
643834
Rattus norvegicus
malonate + adipyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
malonyl-CoA + glutarate
-
643834
Rattus norvegicus
malonate + glutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
malonyl-CoA + methylmalonate
-
643834
Rattus norvegicus
malonate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
malonyl-CoA + succinate
-
643834
Rattus norvegicus
malonate + succinyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
methylmalonyl-CoA + 3-hydroxy-3-methylglutarate
-
643834
Rattus norvegicus
methylmalonate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
methylmalonyl-CoA + adipate
-
643834
Rattus norvegicus
methylmalonate + adipyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
methylmalonyl-CoA + glutarate
-
643834
Rattus norvegicus
methylmalonate + glutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
methylmalonyl-CoA + malonate
-
643834
Rattus norvegicus
methylmalonate + malonyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
methylmalonyl-CoA + succinate
-
643834
Rattus norvegicus
methylmalonate + succinyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
succinyl-CoA + 3-hydroxy-3-methylglutarate
-
643834
Rattus norvegicus
succinate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
succinyl-CoA + 3-hydroxy-3-methylglutarate
involved in regulation of the tricarboxylic acid cycle rate and ketogenesis
643834
Rattus norvegicus
succinate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
succinyl-CoA + adipate
-
643834
Rattus norvegicus
succinate + adipyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
succinyl-CoA + glutarate
forward reaction at 58%, reverse reaction at 55% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
succinate + glutaryl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
succinyl-CoA + malonate
forward reaction at 29%, reverse reaction at 22% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
succinate + malonyl-CoA
-
643834
Rattus norvegicus
r
2.8.3.13
succinyl-CoA + methylmalonate
-
643834
Rattus norvegicus
succinate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r