BRENDA - Enzyme Database

Effects of phospholipids on soluble phosphatidylserine synthetase of Escherichia coli

Ishinaga, M.; Kato, M.; Kito, M.; FEBS Lett. 49, 201-202 (1974)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.8.8
cardiolipin
activates. The enzyme is completely desensitized by treatment for 5 min at 40°C against the effect of cadiolipin without loss of activity
Escherichia coli
2.7.8.8
phosphatidylethanolamine
slightly activates. The enzyme is completely desensitized by treatment for 5 min at 40°C against the effect of phosphatidylethanolamine without loss of activity
Escherichia coli
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.8.8
0.085
-
L-Ser
pH 7.2, 37°C, membrane-bound enzyme
Escherichia coli
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.8.8
CDP-diacylglycerol + L-serine
Escherichia coli
the enzyme participates in the biosynthesis of phosphatidylethanolamine
CMP + 3-O-sn-phosphatidyl-L-serine
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.8.8
Escherichia coli
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.8.8
CDP-1,2-dicaproyl-DL-glycerol + L-Ser
-
643784
Escherichia coli
CMP + 3-O-sn-1,2-dicaproylphosphatidylserine
-
-
-
?
2.7.8.8
CDP-1,2-dipalmitoyl-L-glycerol + L-Ser
-
643784
Escherichia coli
CMP + 1,2-dipalmitoylphosphatidylserine
-
-
-
?
2.7.8.8
CDP-diacylglycerol + L-Ser
-
643784
Escherichia coli
CMP + 3-O-sn-phosphatidyl-L-serine
-
643784
Escherichia coli
?
2.7.8.8
CDP-diacylglycerol + L-serine
the enzyme participates in the biosynthesis of phosphatidylethanolamine
643784
Escherichia coli
CMP + 3-O-sn-phosphatidyl-L-serine
-
-
-
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.8.8
cardiolipin
activates. The enzyme is completely desensitized by treatment for 5 min at 40°C against the effect of cadiolipin without loss of activity
Escherichia coli
2.7.8.8
phosphatidylethanolamine
slightly activates. The enzyme is completely desensitized by treatment for 5 min at 40°C against the effect of phosphatidylethanolamine without loss of activity
Escherichia coli
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.8.8
0.085
-
L-Ser
pH 7.2, 37°C, membrane-bound enzyme
Escherichia coli
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.8.8
CDP-diacylglycerol + L-serine
Escherichia coli
the enzyme participates in the biosynthesis of phosphatidylethanolamine
CMP + 3-O-sn-phosphatidyl-L-serine
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.8.8
CDP-1,2-dicaproyl-DL-glycerol + L-Ser
-
643784
Escherichia coli
CMP + 3-O-sn-1,2-dicaproylphosphatidylserine
-
-
-
?
2.7.8.8
CDP-1,2-dipalmitoyl-L-glycerol + L-Ser
-
643784
Escherichia coli
CMP + 1,2-dipalmitoylphosphatidylserine
-
-
-
?
2.7.8.8
CDP-diacylglycerol + L-Ser
-
643784
Escherichia coli
CMP + 3-O-sn-phosphatidyl-L-serine
-
643784
Escherichia coli
?
2.7.8.8
CDP-diacylglycerol + L-serine
the enzyme participates in the biosynthesis of phosphatidylethanolamine
643784
Escherichia coli
CMP + 3-O-sn-phosphatidyl-L-serine
-
-
-
?