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Literature summary extracted from

  • Lehman, I.R.; Karguni, L.S.
    DNA polymerase alpha (1989), J. Biol. Chem., 264, 4265-4268.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.7 Polymerase alpha accessory factors overview Drosophila melanogaster
2.7.7.7 Polymerase alpha accessory factors overview Mammalia
2.7.7.7 Polymerase alpha accessory factors overview Mus musculus
2.7.7.7 Polymerase alpha accessory factors overview Homo sapiens
2.7.7.7 Polymerase alpha accessory factors overview Saccharomyces cerevisiae
2.7.7.7 Polymerase alpha accessory factors overview Bos taurus
2.7.7.7 Polymerase alpha accessory factors overview Chlorocebus aethiops

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.7 aphidicolin polymerase alpha and delta Bos taurus
2.7.7.7 aphidicolin
-
 Drosophila melanogaster
2.7.7.7 aphidicolin
-
 Homo sapiens
2.7.7.7 aphidicolin
-
 Mammalia
2.7.7.7 aphidicolin
-
 Mus musculus
2.7.7.7 aphidicolin
-
 Saccharomyces cerevisiae
2.7.7.7 N-ethylmaleimide polymerase alpha and delta Bos taurus
2.7.7.7 N-ethylmaleimide
-
 Drosophila melanogaster
2.7.7.7 N-ethylmaleimide
-
 Homo sapiens
2.7.7.7 N-ethylmaleimide
-
 Mammalia
2.7.7.7 N-ethylmaleimide
-
 Mus musculus
2.7.7.7 N-ethylmaleimide
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.7 deoxynucleoside triphosphate + DNAn Drosophila melanogaster
-
 diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Mammalia
-
 diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Mus musculus
-
 diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Homo sapiens
-
 diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Saccharomyces cerevisiae
-
 diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Bos taurus
-
 diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Chlorocebus aethiops
-
 diphosphate + DNAn+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.7 Bos taurus
-
 5 cellular DNA template-dependent DNA polymerases are encoded by distinct genes: polymerase alpha, i.e. pol I, polymerase beta, only in vertebrates, polymerase gamma, required for mitochondrial DNA replication but encoded in the nucleus, polymerase delta, enzymes in mammalian cell contain tightly associated 3'-5'-exonuclease activities, 2 forms: proliferating cell nuclear antigen-dependent and a proliferating cell nuclear antigen-independent, also called DNA polymerase delta II, now named DNA polymerase epsilon, polymerase epsilon, tightly associated 3'-5'-exonuclease activity, formerly named DNA polymerase delta II
-
2.7.7.7 Chlorocebus aethiops
-
 monkey
-
2.7.7.7 Drosophila melanogaster
-
-
-
2.7.7.7 Homo sapiens
-
 5 cellular DNA template-dependent DNA polymerases are encoded by distinct genes: polymerase alpha, i.e. pol I, polymerase beta, only in vertebrates, polymerase gamma, required for mitochondrial DNA replication but encoded in the nucleus, polymerase delta, enzymes in mammalian cell contain tightly associated 3'-5'-exonuclease activities, 2 forms: proliferating cell nuclear antigen-dependent and a proliferating cell nuclear antigen-independent, also called DNA polymerase delta II, now named DNA polymerase epsilon, polymerase epsilon, tightly associated 3'-5'-exonuclease activity, formerly named DNA polymerase delta II
-
2.7.7.7 Mammalia
-
-
-
2.7.7.7 Mus musculus
-
-
-
2.7.7.7 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.7 CV-1 cell
-
 Chlorocebus aethiops
-
2.7.7.7 HeLa cell
-
 Homo sapiens
-
2.7.7.7 hybridoma cell
-
 Mus musculus
-
2.7.7.7 KB cell
-
 Homo sapiens
-
2.7.7.7 thymus
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Drosophila melanogaster diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Mammalia diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Mus musculus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Homo sapiens diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Saccharomyces cerevisiae diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Bos taurus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Chlorocebus aethiops diphosphate + DNAn+1
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.7 More subunit structure of DNA polymerase alpha Drosophila melanogaster
2.7.7.7 More subunit structure of DNA polymerase alpha Mammalia
2.7.7.7 More subunit structure of DNA polymerase alpha Mus musculus
2.7.7.7 More subunit structure of DNA polymerase alpha Homo sapiens
2.7.7.7 More subunit structure of DNA polymerase alpha Saccharomyces cerevisiae
2.7.7.7 More subunit structure of DNA polymerase alpha Bos taurus
2.7.7.7 More subunit structure of DNA polymerase alpha Chlorocebus aethiops