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Literature summary extracted from

  • Tornaletti, S.; Patrick, S.M.; Turchi, J.J.; Hanawalt, P.C.
    Behavior of T7 RNA polymerase and Mammalian RNA polymerase II at site-specific cisplatin adducts in the template DNA (2003), J. Biol. Chem., 278, 35791-35797.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.6 cisplatin a single cisplatin 1,2-d(CG) intrastrand cross-link or a single cisplatin 1,3-d(GTG) intrastrand cross-link is a strong block to the enzyme. The efficiency of the block at a cisplatin 1,2-d(GG) intrastrand cross-link is similar in several different nucleotide sequence contexts. Some blockage is also observed when the single cisplatin 1,3-d(GTG) intrastrand cross-link is located in the non-transcribed strand. Cisplatin-induced lesions in the transcribed DNA strand constitute a strong physical barrier to RNA polymerase progression Escherichia phage T7
2.7.7.6 cisplatin a single cisplatin 1,2-d(CG) intrastrand cross-link or a single cisplatin 1,3-d(GTG) intrastrand cross-link is a strong block to the enzyme. The efficiency of the block at a cisplatin 1,2-d(GG) intrastrand cross-link is similar in several different nucleotide sequence contexts. Some blockage is also observed when the single cisplatin 1,3-d(GTG) intrastrand cross-link is located in the non-transcribed strand. Cisplatin-induced lesions in the transcribed DNA strand constitute a strong physical barrier to RNA polymerase progression Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.6 Escherichia phage T7
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-
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2.7.7.6 Rattus norvegicus
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.6 liver
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Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.6 nucleoside triphosphate + RNAn the enzyme requires DNA as template Rattus norvegicus diphosphate + RNAn+1
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?
2.7.7.6 nucleoside triphosphate + RNAn the enzyme requires DNA as template Escherichia phage T7 diphosphate + RNAn+1
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?