BRENDA - Enzyme Database

Cascade control of E. coli glutamine synthetase. II. Metabolite regulation of the enzymes in the cascade

Engleman, E.G.; Francis, S.H.; Arch. Biochem. Biophys. 191, 602-612 (1978)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.7.59
glutamine
5 mM, no effect at pH 8.6; pH 7.6, enhances uridylyl removing activity at 0.5 mM
Escherichia coli
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.7.59
3-phosphoglycerate
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
acetyl-CoA
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
ADP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
AMP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
ATP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
CDP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
CDP-glucose
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
CMP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
CoA
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
CTP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
D-fructose 1,6-diphosphate
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
dCMP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
dUMP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
GDP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
GMP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
GTP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
IDP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
IMP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
ITP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
NAD+
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
NADH
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
NADP+
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
NADPH
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
phosphoenolpyruvate
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
TDP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
TMP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
TTP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
UDP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
UDP-glucose
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
UMP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
UTP
inhibits uridylyl removing activity
Escherichia coli
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.7.59
Mn2+
-
Escherichia coli
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.7.59
UTP + [protein-PII]
Escherichia coli
the enzyme is involved in the cascade control of glutamine synthetase
diphosphate + uridylyl-[protein-PII]
-
Escherichia coli
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.7.59
Escherichia coli
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.7.59
UTP + [protein-PII]
-
643541
Escherichia coli
diphosphate + uridylyl-[protein-PII]
-
643541
Escherichia coli
r
2.7.7.59
UTP + [protein-PII]
the enzyme is involved in the cascade control of glutamine synthetase
643541
Escherichia coli
diphosphate + uridylyl-[protein-PII]
-
643541
Escherichia coli
r
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.7.59
glutamine
5 mM, no effect at pH 8.6; pH 7.6, enhances uridylyl removing activity at 0.5 mM
Escherichia coli
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.7.59
3-phosphoglycerate
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
acetyl-CoA
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
ADP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
AMP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
ATP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
CDP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
CDP-glucose
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
CMP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
CoA
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
CTP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
D-fructose 1,6-diphosphate
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
dCMP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
dUMP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
GDP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
GMP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
GTP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
IDP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
IMP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
ITP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
NAD+
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
NADH
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
NADP+
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
NADPH
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
phosphoenolpyruvate
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
TDP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
TMP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
TTP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
UDP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
UDP-glucose
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
UMP
inhibits uridylyl removing activity
Escherichia coli
2.7.7.59
UTP
inhibits uridylyl removing activity
Escherichia coli
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.7.59
Mn2+
-
Escherichia coli
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.7.59
UTP + [protein-PII]
Escherichia coli
the enzyme is involved in the cascade control of glutamine synthetase
diphosphate + uridylyl-[protein-PII]
-
Escherichia coli
r
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.7.59
UTP + [protein-PII]
-
643541
Escherichia coli
diphosphate + uridylyl-[protein-PII]
-
643541
Escherichia coli
r
2.7.7.59
UTP + [protein-PII]
the enzyme is involved in the cascade control of glutamine synthetase
643541
Escherichia coli
diphosphate + uridylyl-[protein-PII]
-
643541
Escherichia coli
r