BRENDA - Enzyme Database

Inhibitory effects of flavonoids on Moloney murine leukemia virus reverse transcriptase activity

Chu, S.C.; Hsieh, Y.S.; Lin, J.Y.; J. Nat. Prod. 55, 179--183 (1992)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.7.49
(+)-catechin
-
Moloney murine leukemia virus
2.7.7.49
(+)-taxifolin
-
Moloney murine leukemia virus
2.7.7.49
(-)-epicatechin
-
Moloney murine leukemia virus
2.7.7.49
fisetin
-
Moloney murine leukemia virus
2.7.7.49
flavanonol
low inhibition
Moloney murine leukemia virus
2.7.7.49
flavone
low inhibition
Moloney murine leukemia virus
2.7.7.49
flavonol
-
Moloney murine leukemia virus
2.7.7.49
kaempferol
-
Moloney murine leukemia virus
2.7.7.49
additional information
simultaneous presence of free hydroxyl groups at position 3 and 4' enhance the reverse transcriptase inhibitory activity. Replacement of the 3-hydroxyl group with a monosaccharide or of the 4'-hydroxyl group with a Me group reduces inhibitory activity. The double bond at position 2 and 3 of the flavonoid‘s pyrone ring is not essential for inhibiting reverse transcriptase activity
Moloney murine leukemia virus
2.7.7.49
morin
-
Moloney murine leukemia virus
2.7.7.49
myricetin
-
Moloney murine leukemia virus
2.7.7.49
quercetin
-
Moloney murine leukemia virus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.7.49
Moloney murine leukemia virus
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.7.49
deoxynucleoside triphosphate + DNAn
-
643423
Moloney murine leukemia virus
diphosphate + DNAn+1
-
643423
Moloney murine leukemia virus
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.7.49
(+)-catechin
-
Moloney murine leukemia virus
2.7.7.49
(+)-taxifolin
-
Moloney murine leukemia virus
2.7.7.49
(-)-epicatechin
-
Moloney murine leukemia virus
2.7.7.49
fisetin
-
Moloney murine leukemia virus
2.7.7.49
flavanonol
low inhibition
Moloney murine leukemia virus
2.7.7.49
flavone
low inhibition
Moloney murine leukemia virus
2.7.7.49
flavonol
-
Moloney murine leukemia virus
2.7.7.49
kaempferol
-
Moloney murine leukemia virus
2.7.7.49
additional information
simultaneous presence of free hydroxyl groups at position 3 and 4' enhance the reverse transcriptase inhibitory activity. Replacement of the 3-hydroxyl group with a monosaccharide or of the 4'-hydroxyl group with a Me group reduces inhibitory activity. The double bond at position 2 and 3 of the flavonoid‘s pyrone ring is not essential for inhibiting reverse transcriptase activity
Moloney murine leukemia virus
2.7.7.49
morin
-
Moloney murine leukemia virus
2.7.7.49
myricetin
-
Moloney murine leukemia virus
2.7.7.49
quercetin
-
Moloney murine leukemia virus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.7.49
deoxynucleoside triphosphate + DNAn
-
643423
Moloney murine leukemia virus
diphosphate + DNAn+1
-
643423
Moloney murine leukemia virus
?