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Literature summary extracted from

  • Brown, S.; Blumenthal, T.
    Function and structure in ribonucleic acid Phage Qbeta ribonucleic acid replicase. Effect of inhibitors of EF-Tu on ribonucleic acid synthesis and renaturation of active enzyme (1976), J. Biol. Chem., 251, 2749-2753.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.7.7.48 the EF-Tu*Ts complex rather than the individual polypeptides functions in the renaturation of Qbeta replicase, treatment of pure EF-Tu with kiromycin prevents it from functioning in the renaturation of Qbeta replicase Qubevirus durum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.48 delvomycin the protein synthetic activity of the EF-Tu in the replicase complex is eliminated but the Qbeta RNA replicase activity is only slightly affected Qubevirus durum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn Qubevirus durum composed of one phage-coded polypeptide and three host-supplied polypeptides which function in the biosynthesis of proteins in the uninfected host. Two of theses polypeptides, protein elongation factors EF-Tu and EF-Ts, are required for initiation of transcription by replicase with all templates diphosphate + RNAn+1
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Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 Qubevirus durum
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-
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn
-
 Qubevirus durum diphosphate + RNAn+1
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 ?
2.7.7.48 nucleoside triphosphate + RNAn composed of one phage-coded polypeptide and three host-supplied polypeptides which function in the biosynthesis of proteins in the uninfected host. Two of theses polypeptides, protein elongation factors EF-Tu and EF-Ts, are required for initiation of transcription by replicase with all templates Qubevirus durum diphosphate + RNAn+1
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.48 tetramer composed of one phage-coded polypeptide and three host-supplied polypeptides Qubevirus durum