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Literature summary extracted from

  • Warner, A.H.; Huang, F.L.
    Biosynthesis of the diguanosine nucleotides. II. Mechanism of action of GTP:GTP guanylyltransferase on nucleotide metabolism in brine shrimp embryos (1974), Can. J. Biochem., 52, 241-251.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.45 DTT
-
 Artemia salina

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.45 0.84
-
 diphosphate pH 5.9, 40°C Artemia salina
2.7.7.45 1.06
-
 Gp4G pH 5.9, 40°C Artemia salina
2.7.7.45 2.2
-
 GTP pH 5.9, 40°C Artemia salina

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.45 mitochondrion small amount of activity Artemia salina 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.45 Mg2+ required for the forward reaction Artemia salina

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.45 GTP + GTP Artemia salina
-
 diphosphate + P1,P4-bis(5'-guanosyl)tetraphosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.45 Artemia salina
-
 brine shrimp
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.7.45 2 GTP = diphosphate + P1,P4-bis(5'-guanosyl) tetraphosphate mechanism Artemia salina
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.45 embryo encysted, yolk platelets of Artemia salina
-
2.7.7.45 platelet of yolk Artemia salina
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.45 GDP + P1,P4-bis(5'-guanosyl)tetraphosphate
-
 Artemia salina P1,P3-bis(5'-guanosyl)triphosphate
-
 r
2.7.7.45 GTP + GTP
-
 Artemia salina P1,P4-bis(5'-guanosyl)tetraphosphate + diphosphate i.e. GP4G r
2.7.7.45 GTP + GTP
-
 Artemia salina diphosphate + P1,P4-bis(5'-guanosyl)tetraphosphate
-
 r
2.7.7.45 additional information either 2 enzymes are present in guanosine-triphosphate guanylyltransferase preparations or 2 catalytic sites exist on one protein, one for the synthesis of P1,P3-bis(5'-guanosyl)triphosphate and one for the synthesis of P1,P4-bis(5'-guanosyl)tetraphosphate Artemia salina ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.45 5.9 6
-
 Artemia salina