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Literature summary extracted from

  • Seubert, P.A.; Hoang, L.; Renosto, F.; Segel, I.H.
    ATP sulfurylase from Penicillium chrysogenum: measurements of the true specific activity of an enzyme subject to potent product inhibition and a reassessment of the kinetic mechanism (1983), Arch. Biochem. Biophys., 225, 679-691.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.4 adenosine 5'-phosphosulfate potent product inhibition, competitive with both MgATP2- and MoO42- in molybdolysis assay Penicillium chrysogenum
2.7.7.4 ClO3- competitive with SO42- or MoO42-, competitive against MgATP2- Penicillium chrysogenum
2.7.7.4 ClO4- competitive with SO42- or MoO42-, competitive against MgATP2- Penicillium chrysogenum
2.7.7.4 FSO3- competitive with SO42- or MoO42-, competitive against MgATP2- Penicillium chrysogenum
2.7.7.4 NO3- competitive with SO42- or MoO42-, competitive against MgATP2- Penicillium chrysogenum
2.7.7.4 S2O32- dead-end inhibitor, competitive with SO42- or MoO42-, noncompetitive against MgATP2- Penicillium chrysogenum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.4 0.15
-
 ATP pH 8.0, 30°C Penicillium chrysogenum
2.7.7.4 0.15
-
 ATP ATP in form of MgATP2- Penicillium chrysogenum
2.7.7.4 0.36
-
 SO42- pH 8.0, 30°C Penicillium chrysogenum

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.4 Penicillium chrysogenum
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.7.4 ATP + sulfate = diphosphate + adenylyl sulfate random sequence for the forward reaction with adenylylsulfate release being partially rate limiting Penicillium chrysogenum
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.4 ATP + sulfate
-
 Penicillium chrysogenum diphosphate + adenylylsulfate
-
 r
2.7.7.4 ATP + sulfate
-
 Penicillium chrysogenum diphosphate + adenylyl sulfate
-
 r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.7.4 0.0034
-
 FSO3- pH 8.0, 30°C Penicillium chrysogenum