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Literature summary extracted from

  • Vermeulen, P.S.; Geelen, M.J.H.; van Golde, L.M.G.
    Substrate specificity of CTP: phosphoethanolamine cytidylyltransferase purified from rat liver (1994), Biochim. Biophys. Acta, 1211, 343-349.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.14 phosphocholine weak, competitive to phosphoethanolamine Rattus norvegicus
2.7.7.14 phosphodimethylethanolamine weak, competitive to phosphoethanolamine Rattus norvegicus
2.7.7.14 phosphomonomethylethanolamine weak, competitive to phosphoethanolamine Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.14 0.072
-
 Phosphoethanolamine pH 7.8, 37°C Rattus norvegicus
2.7.7.14 0.11
-
 phosphomonomethylethanolamine pH 7.8, 37°C Rattus norvegicus
2.7.7.14 6.2
-
 phosphocholine pH 7.8, 37°C Rattus norvegicus
2.7.7.14 6.8
-
 phosphodimethylethanolamine pH 7.8, 37°C Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.14 CTP + ethanolamine phosphate Rattus norvegicus
-
 diphosphate + CDP-ethanolamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.14 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.14 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.14 CTP + ethanolamine phosphate
-
 Rattus norvegicus diphosphate + CDP-ethanolamine
-
 ?
2.7.7.14 CTP + phosphocholine
-
 Rattus norvegicus diphosphate + CDP-choline
-
 ?
2.7.7.14 CTP + phosphodimethylethanolamine
-
 Rattus norvegicus diphosphate + CDP-dimethylethanolamine
-
 ?
2.7.7.14 CTP + phosphomonomethylethanolamine
-
 Rattus norvegicus diphosphate + CDP-methylethanolamine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.7.14 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.14 6.5
-
 2 optima: pH 6.5 and pH 8.0 Rattus norvegicus
2.7.7.14 8
-
 2 optima: pH 6.5 and pH 8.0 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.7.14 6.8
-
 phosphodimethylethanolamine pH 7.8, 37°C Rattus norvegicus
2.7.7.14 7
-
 phosphomonomethylethanolamine pH 7.8, 37°C Rattus norvegicus
2.7.7.14 52.9
-
 phosphocholine pH 7.8, 37°C Rattus norvegicus