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Literature summary extracted from

  • Franchetti, P.; Cappellacci, L.; Pasqualini, M.; Grifantini, M.; Lorenzi, T.; Raffaelli, N.; Magni, G.
    Dinucleoside polyphosphate NAD analogs as potential NMN adenylyltransferase inhibitors. Synthesis and biological evaluation (2003), Nucleosides Nucleotides Nucleic Acids, 22, 865-868.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.1 P1-(adenosine-5')-P3-(nicotinamide ribose-5')triphosphate
-
 Homo sapiens
2.7.7.1 P1-(adenosine-5')-P3-(nicotinamide ribose-5')triphosphate
-
 Methanocaldococcus jannaschii
2.7.7.1 P1-(adenosine-5')-P3-(nicotinamide ribose-5')triphosphate
-
 Saccharomyces cerevisiae
2.7.7.1 P1-(adenosine-5')-P4-(nicotinamide ribose-5')tetraphosphate no effect at 0.1 mM Homo sapiens
2.7.7.1 P1-(adenosine-5')-P4-(nicotinamide ribose-5')tetraphosphate 60% inhibition at 0.1 mM Methanocaldococcus jannaschii
2.7.7.1 P1-(adenosine-5')-P4-(nicotinamide ribose-5')tetraphosphate
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide Homo sapiens
-
 diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide Saccharomyces cerevisiae
-
 diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide Methanocaldococcus jannaschii
-
 diphosphate + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.1 Homo sapiens
-
-
-
2.7.7.1 Methanocaldococcus jannaschii
-
-
-
2.7.7.1 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Homo sapiens diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Saccharomyces cerevisiae diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Methanocaldococcus jannaschii diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide i.e. NMN or nicotinamide mononucleotide Homo sapiens diphosphate + NAD+
-
 r
2.7.7.1 ATP + nicotinamide ribonucleotide i.e. NMN or nicotinamide mononucleotide Saccharomyces cerevisiae diphosphate + NAD+
-
 r
2.7.7.1 ATP + nicotinamide ribonucleotide i.e. NMN or nicotinamide mononucleotide Methanocaldococcus jannaschii diphosphate + NAD+
-
 r