Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Garavaglia, S.; D'Angelo, I.; Emanuelli, M.; Carnevali, F.; Pierella, F.; Magni, G.; Rizzi, M.
    Structure of human NMN adenylyltransferase. A key nuclear enzyme for NAD homeostasis (2002), J. Biol. Chem., 277, 8524-8530.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.1
-
 Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.7.1 hanging drop vapor diffusion method, 20 mg/ml protein mixed with an equal volume of reservoir solution containing 1.8 M ammonium sulfate, 0.1 M Tris, pH 8 and 4% v/v isopropyl alcohol, 4-5 days at 20°C, monoclinic space group P21 if 20% glycerol is used, hexagonal space group P6322 if light paraffin oil is used Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide Homo sapiens
-
 diphosphate + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.1 Homo sapiens Q9HAN9
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Homo sapiens diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide i.e. NMN or nicotinamide mononucleotide Homo sapiens diphosphate + NAD+
-
 r
2.7.7.1 ATP + nicotinate ribonucleotide i.e. nicotinate mononucleotide Homo sapiens diphosphate + nicotinic acid-adenine dinucleotide
-
 r

Subunits

EC Number Subunits Comment Organism
2.7.7.1 hexamer alpha/beta-topology subunits, X-ray crystallography, barrel-like hexamer Homo sapiens